"Effect of Nebulized Heparin in Patients with Pneumonia"

Effect of Daily Administration of Nebulized Heparin on Prevention of Endotracheal Tube Blockage by Clot and Mucus Plug Compared to Normal Saline in Patients with Pneumonia

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200821048470N1

Enrollment

Registered

2020-10-12

Start date

2020-10-06

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pneumonia. Ventilator associated pneumonia

Interventions

Intervention 1: Intervention group: in this group, patients receive 5,000 units of heparin ampoules per 1 ml mixed with 4 cc of 0.9% normal saline every 6 hours as a nebulization through a tracheal tu

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with pneumonia who have been intubated and admitted to the ICU. All patients have an apache score less than 25.

Exclusion criteria

Exclusion criteria: Thrombocytopenia or a history of heparin-induced thrombocytopenia Coagulation disorder with INR above 1.5 pregnant women Any active bleeding and history of intracranial hemorrhage during the last 3 months Patients receiving anticoagulants

Design outcomes

Primary

Measure	Time frame
The degree of obstruction of the endotracheal tube by plug or bare mucus. Timepoint: On admission and daily. Method of measurement: Clinical Information Collection Form.;Hypoxia. Timepoint: On admission and daily. Method of measurement: Drop in arterial blood oxygen saturation to less than 90 or more than 4% of basal level after elimination of other common causes.;Infection. Timepoint: On admission and daily. Method of measurement: New VAP event based on different clinic or graph with primary lung infection.	—

Measure

Time frame

The degree of obstruction of the endotracheal tube by plug or bare mucus. Timepoint: On admission and daily. Method of measurement: Clinical Information Collection Form.;Hypoxia. Timepoint: On admission and daily. Method of measurement: Drop in arterial blood oxygen saturation to less than 90 or more than 4% of basal level after elimination of other common causes.;Infection. Timepoint: On admission and daily. Method of measurement: New VAP event based on different clinic or graph with primary lung infection.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHooshmand Hosseininezhad

Ahvaz University of Medical Sciences

hosseininezhad.h@ajums.ac.ir+98 61 3221 5574

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026