Evaluation of the Effectiveness of Hydrocortisone and Dexamethasone in the Management of Patients with Chronic Obstructive Pulmonary Disease Exacerbation.

Evaluation of Effectiveness of Dexamethazone versus Hydrocortisone in Reducing Hospital Length, Oxidative Stress Factors and Inflammatory Mediators in Chronic Obstructive Pulmonary Disease (COPD) Exacerbation Patients.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200818048447N1

Enrollment

Registered

2021-11-10

Start date

2021-03-05

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease. Chronic obstructive pulmonary disease, unspecified

Interventions

Intervention 1: Intervention group: Intervention group 1 includes 35 patients with exacerbation of chronic obstructive pulmonary disease who receive 8 mg of dexamethasone injection,eight gram ampules

Eligibility

Sex/Gender

All

Age

35 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 40 years Confirmed history (FEV1 / FVC <70%) of COPD or typical history (prolonged smoking and chronic sputum and cough) Exacerbations of the disease include increased cough, sputum, and shortness of breath

Exclusion criteria

Exclusion criteria: History of Asthma or Atopy Consumption Systemic Corticosteroids within the Last Month before Hospitalization Recent Myocardial Infarction Not Compensated Acute Heart Failure Diagnosis of Lobar Pneumonia on X-ray or CT scan of the Lungs

Design outcomes

Primary

Measure	Time frame
Dyspnea. Timepoint: Daily till discharge. Method of measurement: Questionnaire. Patients score from 1 to 10 depending on the severity of dyspnea.;Sputum volume. Timepoint: Daily. Method of measurement: Questionnaire. Patients score from 1 to 10 depending on the sputum volume.;Couph. Timepoint: Daily. Method of measurement: Questionnaire. Patients score from 1 to 10 depending on the severity of couph.;Arterial Oxygen Saturation. Timepoint: Daily. Method of measurement: Pulse Oxymeter Device.	—

Measure

Time frame

Dyspnea. Timepoint: Daily till discharge. Method of measurement: Questionnaire. Patients score from 1 to 10 depending on the severity of dyspnea.;Sputum volume. Timepoint: Daily. Method of measurement: Questionnaire. Patients score from 1 to 10 depending on the sputum volume.;Couph. Timepoint: Daily. Method of measurement: Questionnaire. Patients score from 1 to 10 depending on the severity of couph.;Arterial Oxygen Saturation. Timepoint: Daily. Method of measurement: Pulse Oxymeter Device.

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Secondary

Measure	Time frame
Duration of Hospitalization. Timepoint: Time of Discharge. Method of measurement: Counting the days of hospitalization.;Sleep quality. Timepoint: Daily. Method of measurement: Patients score from 1 to 10 depending on their sleep quality.;Peripheral white blood cell count. Timepoint: Day of hospitalization and day of discharge. Method of measurement: Auto-analyzer device in the form of thousand in microliters.;Peak Expiratory Flow. Timepoint: Daily. Method of measurement: Peakflowmeter device.;Edema. Timepoint: Daily. Method of measurement: Physician evaluation. Scoring from 1 to 4.;Peripheral Blood Potassium. Timepoint: Day of hospitalization and day of discharge. Method of measurement: Electrolyte analyzer.;Systemic Blood Pressure. Timepoint: Daily. Method of measurement: Mercury sphygmomanometer.;General well being. Timepoint: Daily. Method of measurement: Questionnaire. Patients score from 1 to 10 depending on their general well being.;Peripheral blood malone dialdehyde. Timepoint: Day of hospitalization and day of discharge. Method of measurement: Measurement with hydrochloric acid reagent.;C Reactive Protein. Timepoint: Day of hospitalization and day of discharge. Method of measurement: Measurement by ELISA sandwich method.	—

Measure

Time frame

Duration of Hospitalization. Timepoint: Time of Discharge. Method of measurement: Counting the days of hospitalization.;Sleep quality. Timepoint: Daily. Method of measurement: Patients score from 1 to 10 depending on their sleep quality.;Peripheral white blood cell count. Timepoint: Day of hospitalization and day of discharge. Method of measurement: Auto-analyzer device in the form of thousand in microliters.;Peak Expiratory Flow. Timepoint: Daily. Method of measurement: Peakflowmeter device.;Edema. Timepoint: Daily. Method of measurement: Physician evaluation. Scoring from 1 to 4.;Peripheral Blood Potassium. Timepoint: Day of hospitalization and day of discharge. Method of measurement: Electrolyte analyzer.;Systemic Blood Pressure. Timepoint: Daily. Method of measurement: Mercury sphygmomanometer.;General well being. Timepoint: Daily. Method of measurement: Questionnaire. Patients score from 1 to 10 depending on their general well being.;Peripheral blood malone dialdehyde. Timepoint: Day of hospitalization and day of discharge. Method of measurement: Measurement with hydrochloric acid reagent.;C Reactive Protein. Timepoint: Day of hospitalization and day of discharge. Method of measurement: Measurement by ELISA sandwich method.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMoslem Sedqattalab

Yasouj University of Medical Sciences

a.hoseyni80@gmail.com+98 74 3333 7231

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026