Investigation and comparison of intravenous infusion of sodium pentotal on the neurological outcomes of patients undergoing decompressive craniectomy

Investigation and comparison of intravenous infusion of sodium pentotal on the neurological outcomes of patients undergoing decompressive craniectomy with intra-operative brain swelling in Ahvaz Golestan hospital in 2020

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200817048436N1

Enrollment

Registered

2020-11-04

Start date

2020-05-10

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Craniocerebral Trauma. Traumatic cerebral edema with loss of consciousness of any duration with death due to brain injury prior to regaining consciousness, initial encounter

Interventions

Intervention 1: Intervention group: In the intervention group, patients received continuous thiopental infusion (Ciron company) at a dose of 2 mg / kg / h asbarbiturate coma therapy (BCT) for 2 hours

Eligibility

Sex/Gender

All

Age

12 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with increased ICP that undergo decompressive craniotomy

Exclusion criteria

Exclusion criteria: Age less than 12 years and over 65 years Dissatisfaction of the patient or his guardian to participate in the study Patients with a known psychiatric history Patients with degenerative underlying brain disease No swelling of the brain during surgery Pregnant mothers Patients with Glasgow Coma Scale/Score: 3 at baseline Patients with Glasgow Coma Scale/Score: 4 and bilateral pupillary mydriasis at baseline

Design outcomes

Primary

Measure	Time frame
Glascow Coma Scale. Timepoint: From the moment of starting treatment until the time of hospitalization and also during 1 and 3 months after that. Method of measurement: Scoring between 3 and 15.;Glasgow Outcome Scale. Timepoint: From the moment of starting treatment until the time of hospitalization and also during 1 and 3 months after that. Method of measurement: Clinical examination of the patient.	—

Measure

Time frame

Glascow Coma Scale. Timepoint: From the moment of starting treatment until the time of hospitalization and also during 1 and 3 months after that. Method of measurement: Scoring between 3 and 15.;Glasgow Outcome Scale. Timepoint: From the moment of starting treatment until the time of hospitalization and also during 1 and 3 months after that. Method of measurement: Clinical examination of the patient.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Yousef Seidi

Ahvaz University of Medical Sciences

seidi19850@gmail.com+98 61 3374 3001

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026