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Efficacy of Daclatasvir+Sofosbuvir in patients with severe acute respiratory syndrome coronavirus (SARS-COVID-19)

Efficacy of Daclatasvir+Sofosbuvir in patients with severe acute respiratory syndrome coronavirus (SARS-COVID-19)

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200816048422N1
Enrollment
70
Registered
2020-10-16
Start date
2020-06-25
Completion date
Unknown
Last updated
2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID -19, virus identified

Interventions

Intervention 1: Patients in the intervention group receive one Daclatasvir / Sofosbuvir 60/400 mg tablet (Danesh Pharmaceutical Development Company) daily for 7 days. Intervention 2: Control group: Re

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age over 18 years old Respiratory rate more than 30 per minute Oxygen saturation less than 93% Confirmation of pneumonia by diagnostic CT scan of the chest

Exclusion criteria

Exclusion criteria: Taking the drug Amiodarone Kidney failure

Design outcomes

Primary

MeasureTime frame
Respiratory rate. Timepoint: 14th day. Method of measurement: physical exam.;Arterial oxygen. Timepoint: 7th day. Method of measurement: Physical examination.;Requires mechanical ventilation. Timepoint: 7th day. Method of measurement: Physical examination.;Death. Timepoint: 7th day. Method of measurement: Physical examination.;Chest changes. Timepoint: 7th day. Method of measurement: Physical examination.

Secondary

MeasureTime frame
Secondary consequences include the need for mechanical ventilation, chest changes (day 14 or earlier as determined by the physician), serious accidents, and mortality. Timepoint: 14th day. Method of measurement: Physical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Zahrz Fakhrae

Ahvaz University of Medical Sciences

z.fakhrae@yahoo.com+98 61 3333 5935

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026