traumatic brain injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Intervention group: daily 10 mg glibenclamide for 10 days. Intervention 2: Control group: placebo Prescription.
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: All TBI patients with moderate(9-12)to severe(4-8) GCS referred to the emergency department of Golestan Hospital in Ahvaz with a maximum of 24 hours after TBI.
Exclusion criteria
Exclusion criteria: Patients with diabetes mellitus, patients that required surgery, spinal cord injury, patients with any known history of renal or hepatic diseases, patients with past medical history of brain tumors, blood glucose 500 mg/dL on admission; internal organs diseases, penetrating brain injury, creatinine >2.5mg/dL or on hemodialysis, total bilirubin >1.5 times of normal value, infections, or previous craniotomy; pregnant patients or patients who intended to breastfeed after being discharged; patients with international normalized ratio >1.5 or use of antiplatelets or anti coagulants within 7 days before admission, history of glucose-6-phosphate dehydrogenase deficiency or any diagnosed allergy to sulfonylurea; patients with contusions in brainstem or an systolic blood pressure <90 mm Hg without response to fluid resuscitation; and patients with contraindications to oral route for taking the medication or treatment with other investigational agents during hospitalization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glasgow outcome scale. Timepoint: Three months after TBI. Method of measurement: Glasgow outcome scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHesam Rasoulian
Ahvaz University of Medical Sciences
Outcome results
None listed