Intravenous Hypertonic saline solution in management of patients with Diuretic Resistant Generalized Edema

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200812048380N1

Enrollment

Registered

2020-10-10

Start date

2021-01-04

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

GENERALIZED EDEMA RESISTANT TO THERAPY.

Interventions

Intervention 1: Control group: they will undergo with treatment by 250mg fursomide q12h plus 150cc normal saline for 48 hours. Intervention 2: Intervention group: they will undergo with treatment by

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: The target population for this trial was patients older than 18 years old with diffuse peripheral edema who did not respond adequately to 80 mg oral furosemide.

Exclusion criteria

Exclusion criteria: subjects candidate for hemodialysis systolic blood pressure =80 mmHg GFR =15ml/min serum albumin =2.5g/dL serum potassium =5.5mEq/L serum sodium greater than 145mEq/L anuric patients (urine volume =100 ml per 24 hours

Design outcomes

Primary

Measure	Time frame
Weight loss. Timepoint: daily. Method of measurement: scale.;Serum cr. Timepoint: before and after treatment. Method of measurement: blood sample.;C systatin. Timepoint: before and after treatment. Method of measurement: blood sample.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahshad Ghoddusi

Tehran University of Medical Sciences

mahshad.ghoddusi@gmail.com+98 21 7745 0199

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026