Assessment of the effects of combination of topical minoxidil, biotin in comparison with topical minoxidil on mild to moderate androgenetic alopecia patients referring to dermatological clinics of Alzahra hospita

Assessment of the effects of combination of topical minoxidil, biotin in comparison with topical minoxidil on mild to moderate androgenetic alopecia patients referring to dermatological clinics of Alzahra hospital

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200811048371N1

Enrollment

Registered

2020-11-17

Start date

2020-07-15

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Androgenetic alopecia. Androgenic alopecia, unspecified

Interventions

Intervention 1: Intervention group: The combination of minoxidil and biotin in a cc twice a day, due to the fact that minoxidil is dissolved in an alcoholic solvent and biotin in an aqueous solvent, t

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Patients with androgenetic alopecia Patients who have not been treated with finasteride or other anti-androgen therapy for the past 6 months

Exclusion criteria

Exclusion criteria: Patients with other types of alopecia (such as alopecia areata, telogen effluvium, anagen effluvium, and scarring alopecia) Receiving systemic treatment for androgenetic alopecia during the last 6 months History of allergy to minoxidil, biotin

Design outcomes

Primary

Measure	Time frame
Standard photographic score (reported by physician). Timepoint: The effect of these two classes of drugs is measured at the end of week 24. Method of measurement: Physician evaluation of hair regrowth at the end of week 24: In this method, a physician who is blind to the study by comparing pre- and post-treatment photographs (taken by Standardized global photography in 4 views) according to a 7- point scale gives points (14). Given that all patients are examined by a physician, the probability of error in subjective assessment is low.Greatly decreased = -3Moderately decreased = -2Slightly decreased = -1No change = 0Slightly increased = +1Moderately increased = +2Greatly increased = +3.;Hair regrowth score from patients' point of view. Timepoint: The effect of these two classes of drugs is measured at the end of week 24. Method of measurement: Evaluate the patient for hair regrowth at the end of week 24: In this method, the patient scores according to a 7-point scale: Greatly decreased = -3Moderately decreased = -2Slightly decreased = -1No change = 0Slightly increased = + 1Moderately increased = + 2Greatly increased = +3.;Number of hair. Timepoint: The effect of these two classes of drugs is measured at the end of week 24. Method of measurement: Hair count at the end of week 24 and comparison with the number of hairs at the beginning of the study: The results will be obtained through the hair polarizer (KC Technology).	—

Measure

Time frame

Standard photographic score (reported by physician). Timepoint: The effect of these two classes of drugs is measured at the end of week 24. Method of measurement: Physician evaluation of hair regrowth at the end of week 24: In this method, a physician who is blind to the study by comparing pre- and post-treatment photographs (taken by Standardized global photography in 4 views) according to a 7- point scale gives points (14). Given that all patients are examined by a physician, the probability of error in subjective assessment is low.Greatly decreased = -3Moderately decreased = -2Slightly decreased = -1No change = 0Slightly increased = +1Moderately increased = +2Greatly increased = +3.;Hair regrowth score from patients' point of view. Timepoint: The effect of these two classes of drugs is measured at the end of week 24. Method of measurement: Evaluate the patient for hair regrowth at the end of week 24: In this method, the patient scores according to a 7-point scale: Greatly decreased = -3Moderately decreased = -2Slightly decreased = -1No change = 0Slightly increased = + 1Moderately increased = + 2Greatly increased = +3.;Number of hair. Timepoint: The effect of these two classes of drugs is measured at the end of week 24. Method of measurement: Hair count at the end of week 24 and comparison with the number of hairs at the beginning of the study: The results will be obtained through the hair polarizer (KC Technology).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Mokhtari

Esfahan University of Medical Sciences

f_mokhtari2004@yahoo.com+98 31 3629 4542

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026