Effect of interval and continuous training on endothelial function in patients with type 2 diabetes

The effect of 12-weeks of interval and continuous training on vaspin, Asymmetric dimethyl-arginine and relationship with flow-mediated dilation in patients with type 2 diabetes

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200810048351N1

Enrollment

Registered

2020-11-15

Start date

2019-06-26

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes. Type 2 diabetes mellitus

Interventions

Intervention 1: Intervention group1: High- volume high- intensity interval training that consists of 12 intervals 1.5 minutes at 85- 90% HRmax which separated by 2 minutes at 55-60% HRmax. Exercise tr

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: History of type 2 diabetes more than 2 years No history of 6 months of regular exercise Glycosylated hemoglobin above 6%(HbA1C >6%) Body mass index over 25 Pre hypertension or I stage

Exclusion criteria

Exclusion criteria: HbA1C over 10% Fasting blood glucose more than 400 mg/dl Functional limitations (such as osteoarthritis) Liver and kidney disease Myocardial infarction Coronary artery bypass surgery or angioplasty Chronic heart failure Cardiac arrhythmia's Smoking Uncontrolled BP (BP > 170/100 mmHg) Insulin therapy

Design outcomes

Primary

Measure	Time frame
Vaspin. Timepoint: Before and after 12-weeks intervention. Method of measurement: ELISA kit.;Asymmetric dimethy-argenin. Timepoint: Before and after 12-weeks intervention. Method of measurement: ELISA kit.;Nitrite/nitrate. Timepoint: Before and after 12-weeks intervention. Method of measurement: ELISA kit.;Flow-mediated dilation. Timepoint: Before and after 12-weeks intervention. Method of measurement: Ultrasound doppler.;Insuline resistance. Timepoint: Before and after 12-weeks. Method of measurement: HOMA-IR.;Insulin. Timepoint: Before and after 12-weeks intervention. Method of measurement: ELISA kit.;Glucose. Timepoint: Before and after 12-weeks intervention. Method of measurement: ELISA kit.;Peak oxygen consumption. Timepoint: Before and after 12-week intervention. Method of measurement: Gas analyser system.	—

Measure

Time frame

Vaspin. Timepoint: Before and after 12-weeks intervention. Method of measurement: ELISA kit.;Asymmetric dimethy-argenin. Timepoint: Before and after 12-weeks intervention. Method of measurement: ELISA kit.;Nitrite/nitrate. Timepoint: Before and after 12-weeks intervention. Method of measurement: ELISA kit.;Flow-mediated dilation. Timepoint: Before and after 12-weeks intervention. Method of measurement: Ultrasound doppler.;Insuline resistance. Timepoint: Before and after 12-weeks. Method of measurement: HOMA-IR.;Insulin. Timepoint: Before and after 12-weeks intervention. Method of measurement: ELISA kit.;Glucose. Timepoint: Before and after 12-weeks intervention. Method of measurement: ELISA kit.;Peak oxygen consumption. Timepoint: Before and after 12-week intervention. Method of measurement: Gas analyser system.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahnaz Najafi

Islamic Azad University

yazda.setayesh98@gmail.com+98 21 4486 5154

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026