Neonatal sepsis. Other sepsis
Conditions
Interventions
Intervention 1: Intervention group: the intervention group received 1 mg/kg zinc gluconate manufactured by Alhawi (1 mg/ml) orally, via a nasogastric or orogastric tube, twice a day for one week. Int
Sponsors
Technology and Research Vice-chancellery, Hormozgan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
1 Days to 28 Days
Inclusion criteria
Inclusion criteria: Presence of at least 2 clinical signs of sepsis including pallor or generalized jaundice, cardiovascular manifestations (tachy- or bradycardia, poor perfusion, or shock), change in body temperature (hypo- or hyperthermia), respiratory manifestations (grunting, intercostal retraction, apnea, or cyanosis), neurologic manifestations (hypotonia, lethargy, irritability, or seizure), gastrointestinal symptoms (abdominal distension, hepatosplenomegaly) CRP >5 mg/ml Presence of at least 1 positive serum parameter based on Fanarrof (book) including WBC 25000 at birth or WBC>30000 12-24 hours after birth or WBC>21000 on the second day of birth or the following days, absolute neutrophil count (ANC) 37 weeks Age <28 days Informed consent of the parents
Exclusion criteria
Exclusion criteria: Important congenital anomalies such as trisomies Hypoxic ischemic encephalopathy Intracranial hemorrhage Respiratory distress syndrome Inborn errors of metabolism Candidiasis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality. Timepoint: At the end of the study. Method of measurement: Based on patient's medical chart. | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to improvement of clinical symptoms. Timepoint: At the end of the study. Method of measurement: Daily clinical examination.;Hospital length of stay. Timepoint: At the end of the study. Method of measurement: Based on the patient's clinical charts. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSimin Yazdi
Bandar Abbas Pediatric Hospital
Outcome results
None listed