Major depression disorder. Major depressive disorder, single episode, severe without psychotic features
Conditions
Interventions
Intervention 1: Control group: 40 patients who receive Placebo similar to the main medicine from any aspect (taste, color and shape). they receive placebo( once daily)in addition to their standard MD
both as oral agent.
Sponsors
Karaj University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: patients with MDD based on DSM V criteria while Hamilton score is equal to 22 or more than 22.
Exclusion criteria
Exclusion criteria: Being psychotic Having Other disorders in axis 1 or 2 Using other psychedelic drugs Has taken Anti depressant agents in last month Or ECT in the 2 last months. Hypothyroidism Positive Cardiovascular disease history Pregnancy or Lactation Renal disease Diabetes type 1 Age 60 years old IQ <70 Medical history of seizure and CNS disorders Using Betablocker agents Using drugs rather than Nicotine and Caffeine Urinary tract infection Mao inhibitors such as Azilect ,Marplan ,Aspirin ,Gabapentin , Pantoprazole ,Omeprazole Pancreatitis Hypotension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton score. Timepoint: 1st visit and 4 and8 weeks after Empagliflozin/Placebo administration. Method of measurement: Hamilton score questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton score. Timepoint: 1st day 4th week and 8th week after administration of Empagliflozin /Placebo. Method of measurement: 24 question Hamilton test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Atefeh Zandifar
Karaj University of Medical Sciences
Outcome results
None listed