Patients with brain tumors (primary or metastatic). Malignant neoplasm of brain
Conditions
Interventions
Intervention 1: Patients with brain tumors whose diagnosis has been previously confirmed using standard diagnostic methods, including contrast-enhanced magnetic resonance imaging (CeMRI) and/or histop
Sponsors
Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with a confirmed or suspected brain tumor recommended for SPECT or other imaging evaluation.3. Ability to provide informed consent. Ability to provide informed consent No prior allergic reaction to technetium-based radiopharmaceuticals Clinical stability allowing participation in imaging procedures.
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding. Severe renal or hepatic impairment. Participation in another clinical trial within the last 30 days. Known hypersensitivity to any component of the radiopharmaceutical formulation. Patients unable to lie still for imaging or with conditions preventing safe imaging. Any condition judged by the investigator to interfere with study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of tumor uptake of 99mTc-DTPA-bis(Methionine) using Gamma camera imaging for detecting malignant lesions. assessment of tracer specificity and sensitivity for LAT1-overexpressing tumors. Timepoint: Static Gamma Camera imaging at 1 hour and 4 hours post-injection. Method of measurement: Qualitative and semi-quantitative assessment of tracer uptake on Gamma Camera images, including tumor visualization and tumor-to-background comparison. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of physiological biodistribution and clearance pattern of 99mTc-DTPA-bis(Methionine) in human subjects using Gamma Camera imaging, including renal excretion and background activity in major organs. Timepoint: Image-based assessment at 1 hour and 4 hours post-injection. Method of measurement: Visual and semi-quantitative interpretation of Gamma camera images to assess tracer distribution in kidneys, liver, soft tissues, and other background regions. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZohreh Noaparast
Mazandaran University of Medical Sciences
Outcome results
None listed