Type 2 diabetes mellitus with nephropathy. Type 2 diabetes mellitus with diabetic neuropathy, unspecified
Conditions
Interventions
Intervention 1: Intervention group: Daily intake of active vitamin D 0.25 mg for 14 weeks in addition to routine treatments consist of Insulin and Valsartan according to dose that patients took before
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Being 30 to 70 years old Having type 2 diabetes that at least 3 months have passed since the diagnosis Proteinuria Plasma hydroxy vitamin D levels above 20 Serum calcium less than 10 and phosphorus less than 5.5 Consent to participate in the study
Exclusion criteria
Exclusion criteria: Hypercalcemia Uncontrolled blood pressure Hyperparathyroidism Kidney stone disease Chronic kidney disease Chronic liver disease Heart failure Calcium and phosphorus metabolic disorders such as osteoporosis and bone metastasis PTH being suppressed Pregnancy Breastfeeding Malignancy History of hormone therapy and supplementation with active vitamin D or calcium HbA1c > % 7/5 Urinary tract Infection Prescribe calcium channel blocker
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proteinuria. Timepoint: At the beginning of the study (before the start of the intervention) and 1, 2 and 3 months after the start of taking active vitamin D. Method of measurement: Measurement of protein in 24-hour urine. | — |
Secondary
| Measure | Time frame |
|---|---|
| Glomerular filtration rate (GFR). Timepoint: At the beginning of the study (before the start of the intervention) and 1, 2 and 3 months after the start of taking active vitamin D. Method of measurement: Based on test results. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMina Khodhal
Ahvaz University of Medical Sciences
Outcome results
None listed