The effect of injectable vitamins E and C on serum cortisol levels, Interleukin-6 and duration of hospitalization in patients with severe traumatic lung contusion

The effect of injectable vitamins E and C on serum cortisol levels, Interleukin-6 and duration of hospitalization in patients with severe traumatic lung contusion: Randomized Controlled Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200731048260N2

Enrollment

192

Registered

2021-09-29

Start date

2021-10-17

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Trauma patients with rib fracture and lung contusions.

Interventions

Intervention 1: Intervention group1: 50 people receive 500 mg of vitamin C intramuscularly. Intervention 2: Intervention group2: 50 people receive 100 iu of vitamin E intramuscularly. Intervention 3:

Eligibility

Sex/Gender

All

Age

12 Years to No maximum

Inclusion criteria

Inclusion criteria: trauma patients with at least 2 broken ribs trauma patients with lung cantusions based on ct scan pictures

Exclusion criteria

Exclusion criteria: patients under 12 patients that dont want to participate

Design outcomes

Primary

Measure	Time frame
Interlukin 6. Timepoint: first ,second and third day of addmition. Method of measurement: Labrotory.;C reactive protein (crp). Timepoint: first ,second and third day of addmition. Method of measurement: Labrotory.;Serum cortisol. Timepoint: first ,second and third day of addmition. Method of measurement: Labrotory.;Atrial Bl00d Gasses (ABG). Timepoint: first ,second and third day of addmition. Method of measurement: Lab test.;Duration of hospitalization. Timepoint: Upon clearance. Method of measurement: Based on the number of days of hospitalization.	—

Measure

Time frame

Interlukin 6. Timepoint: first ,second and third day of addmition. Method of measurement: Labrotory.;C reactive protein (crp). Timepoint: first ,second and third day of addmition. Method of measurement: Labrotory.;Serum cortisol. Timepoint: first ,second and third day of addmition. Method of measurement: Labrotory.;Atrial Bl00d Gasses (ABG). Timepoint: first ,second and third day of addmition. Method of measurement: Lab test.;Duration of hospitalization. Timepoint: Upon clearance. Method of measurement: Based on the number of days of hospitalization.

—

Secondary

Measure	Time frame
Duration of hospitalization in the intensive care unit. Timepoint: When leaving the intensive care unit. Method of measurement: Based on the number of hospitalization days.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBenyamin Seyfari

Bagheiat-allah University of Medical Sciences

seyfari@ptsoc.com+98 21 2259 6152

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026