Effect of ethanol and DMSO in prophylaxis and treatment of COVID-19

Prophylaxis and treatment of COVID-19 using a nasal spray containing 3% dimethyl sulfoxide (DMSO) and 20% ethanol solution

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200727048217N1

Enrollment

610

Registered

2020-09-13

Start date

2020-08-22

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Covid-19. U07.1 COVID-19, virus identified

Interventions

Intervention 1: Intervention group: patients will receive nasal spray containing 20% ??ethanol (German Merck), 3% dimethyl sulfoxide (German Merck) based on physiological serum. Three times a day (eve

Eligibility

Sex/Gender

All

Age

20 Years to No maximum

Inclusion criteria

Inclusion criteria: COVID-19 Patients Close contact with COVID-19 Patinets No current and previous infection with COVID-19 (for the preventive phase)

Exclusion criteria

Exclusion criteria: immigrant patients pregnant patients Anxiety and obsessive-compulsive disorder Protocol noncompliance

Design outcomes

Primary

Measure	Time frame
The mortality rate from Covid-19 patients. Timepoint: 2 weeks after intervention. Method of measurement: Survived or died according to the records.;- Recovery rate from Covid-19. Timepoint: 2 weeks after intervention. Method of measurement: qRT-PCR.;COVID-19 incidence in health employees. Timepoint: In intervention period. Method of measurement: qRT-PCR.	—

Secondary

Measure	Time frame
General Health. Timepoint: At the start and the end of study. Method of measurement: Check list according to the Likert scale.;O2 Saturation. Timepoint: Daily, 8,14 and 21 O'clock. Method of measurement: Pals Oxy-meter.;Respiratory Rate. Timepoint: Daily, 8,14 and 21 O'clock. Method of measurement: Physical examination and berth count.;Temperature. Timepoint: Daily, 8,14 and 21 O'clock. Method of measurement: Thermometer.;Length of hospitalization. Timepoint: At the end of study. Method of measurement: Date of hospitalization and discharge stated in the patient file.;The need for intensive care and respiratory support. Timepoint: At the end of study. Method of measurement: Date of transfer to the ICU and discharge stated in the patient file.;Time of separation from the ventilator. Timepoint: At the end of study. Method of measurement: Date stated in the patient file.;Lymphocyte. Timepoint: At the beginning and end of the study. Method of measurement: Cell counter.	—

Measure

Time frame

General Health. Timepoint: At the start and the end of study. Method of measurement: Check list according to the Likert scale.;O2 Saturation. Timepoint: Daily, 8,14 and 21 O'clock. Method of measurement: Pals Oxy-meter.;Respiratory Rate. Timepoint: Daily, 8,14 and 21 O'clock. Method of measurement: Physical examination and berth count.;Temperature. Timepoint: Daily, 8,14 and 21 O'clock. Method of measurement: Thermometer.;Length of hospitalization. Timepoint: At the end of study. Method of measurement: Date of hospitalization and discharge stated in the patient file.;The need for intensive care and respiratory support. Timepoint: At the end of study. Method of measurement: Date of transfer to the ICU and discharge stated in the patient file.;Time of separation from the ventilator. Timepoint: At the end of study. Method of measurement: Date stated in the patient file.;Lymphocyte. Timepoint: At the beginning and end of the study. Method of measurement: Cell counter.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMoslem Jafarisani

Shahroud University of Medical Sciences

moslem.jafarisani@gmail.com+98 21 8670 5503

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026