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Antioxidants in acute aluminum phosphide poisoning

N-acetylcysteine as an adjuvant therapy in acute aluminum phosphide poisoning: A randomized clinical trial

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200724048192N1
Enrollment
48
Registered
2020-08-30
Start date
2020-09-01
Completion date
Unknown
Last updated
2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute aluminum phosphide poisoning. Toxic effect of pesticides

Interventions

Intervention 1: Control group: Patients will receive the standard treatment, which is determined by the attending physician who maintains clinical responsibility for all patients. It consists of patie

Sponsors

Menoufia Faculty of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to No maximum

Inclusion criteria

Inclusion criteria: History of taking aluminum phosphide tablet(s) and clinical manifestations of acute aluminum phosphide poisoning Reliable identification of the compound either by the container brought by patient attendants or subsequent confirmation with positive silver nitrate test on gastric sample in case of oral route exposure

Exclusion criteria

Exclusion criteria: Patients less than 12 years old Pregnant and lactating women Patients suffering from chronic diseases (e.g. diabetes mellitus, cardiovascular diseases, and hepatic or renal failure) Tablet(s) was/were dissolved in water before ingestion Ingestion of air-exposed aluminium phosphide tablets Time passed since ingestion more than 8 hours Patient who refused to participate

Design outcomes

Primary

MeasureTime frame
All-cause mortality during hospital admission. Timepoint: At the end of the hospitalization period. Method of measurement: Clinical assessment.

Secondary

MeasureTime frame
Proportion of patients requiring intubation. Timepoint: Before the intervention and one day after completion of the intervention. Method of measurement: Clinical evaluation.;Duration of ventilation. Timepoint: Before the intervention and one day after completion of the intervention. Method of measurement: Clinical evaluation.;Duration of hospitalization. Timepoint: At the end of the hospitalization period. Method of measurement: Clinical evaluation.

Countries

Egypt

Contacts

Public ContactSoha Hamid

Menoufia University Faculty of Medicine

d_sh_2007@yahoo.com+20 48 2052265

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026