Hypertension. Essential (primary) hypertension
Conditions
Interventions
Intervention 1: Intervention group: Taking captopril 25 mg orally and in a single dose. Intervention 2: Intervention group: Taking carodilol 6.25 mg orally and in a single dose.
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Refer to the hospital emergency department with symptoms of blood pressure equal to or greater than 160/90 mmHg in patients with hypertension or blood pressure equal to or greater than 180/110 mmHg in patients with new onset of the disease in the age range of 18 to 65 years. Obtaining written consent from patients. Complete the file and information contained in the questionnaire form.
Exclusion criteria
Exclusion criteria: Failure to obtain written consent from patients Defects in the file and information contained in the questionnaire form Patients with acute chest pain Bradycardia History of heart block or sick sinus syndrome Irreversible heart failure Pulmonary edema Aortic dissection Patients who need intravenous drugs to control blood pressure or require high doses of ACEIs and ARBs (captopril> 50 mg / d, enalapril> 10 mg / d, lisinopril> 5 mg / d, losartan> 50 mg / d, valsartan > 80 mg / d). Loss of consciousness Seizure Cerebrovascular accidents (ischemia or bleeding) Acute or chronic renal failure Previous history of pheochromocytoma History of bilateral renal artery stenosis Pregnancy Hypertension after surgery Diastolic blood pressure above 120 History of allergies to captopril and carvedilol and allergies to penicillin and sulfonamides. Asthma or other bronchospasm diseases Existence of cardiogenic shock Severe liver failure Papillary edema Anuria
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Satisfaction rate. Timepoint: At intervals and ends of measurements. Method of measurement: questionnaire.;Drug side effects. Timepoint: At intervals and ends of measurements. Method of measurement: questionnaire. | — |
Primary
| Measure | Time frame |
|---|---|
| Systolic blood pressure. Timepoint: In 10, 20, 30, 45, 60, 90, 120 and 180 minutes after drug administration. Method of measurement: With a hand pressure gauge and with a scale of millimeters of mercury.;Diastolic blood pressure. Timepoint: In 10, 20, 30, 45, 60, 90, 120 and 180 minutes after drug administration. Method of measurement: With a hand pressure gauge and with a scale of millimeters of mercury.;Mean blood pressure. Timepoint: In 10, 20, 30, 45, 60, 90, 120 and 180 minutes after drug administration. Method of measurement: After measuring systolic and diastolic blood pressure its measured with the sum of twice the diastolic blood pressure and the systolic blood pressure divided by three ((2DBP + SBP)/3) will be calculated.;Heart rate. Timepoint: In 10, 20, 30, 45, 60, 90, 120 and 180 minutes after drug administration. Method of measurement: By counting the number of radial pulses. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNasrin Razavianzadeh
Islamic Azad University
Outcome results
None listed