Urgency Hypertension. Essential (primary) hypertension
Conditions
Interventions
Intervention 1: Intervention group:Taking captopril 25 mg orally and in a single dose. Intervention 2: Intervention group:Take hydrochlorothiazide 25 mg orally and in a single dose.
Sponsors
Islamic Azad University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients with known hypertension with a blood pressure of 160/90 mm Hg or more and patients with the new-onset sever hypertention with a blood pressure of 180/110 mm Hg or more without organ damage (urgency) will be included in the study if satisfied. Patients between the ages of 18 and 65 will be included in the study.
Exclusion criteria
Exclusion criteria: Patients who need intravenous drugs to control their blood pressure or other blood pressure medications for different reasons. Patients who need high dose of ACEIs or ARBs (> 50 mg/d Captopril, > 10 mg/d Enalapril, > 5 g/dLisinopril, > 50 mg/d Losartan, > 80 mg/d Valsartan),to control their blood pressure. Patients with myocardial infarction presenting with acute chest pain. Patients with severe renal or hepatic failure,anuria, papillaryedema, pulmonary edema, loss of consciousness, seizure,aortic dissection, or bilateral renal artery stenosis; pregnantpatients, patients with a history of overt allergy or angioedemawith ACEIs, Allergy to penicillins and sulfonamides.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Systolic Blood Pressure. Timepoint: In 10, 20, 30, 45, 60, 90, 120, 180 minutes after drug administration. Method of measurement: With a hand pressure guage and with ascale of millimeters of mercury.;Diastolic Blood Pressure. Timepoint: In 10, 20, 30, 45, 60, 90, 120, 180 minutes after drug administration. Method of measurement: With a hand pressure guage and with ascale of millimeters of mercury.;Mean Blood Pressure. Timepoint: 10, 20, 30, 45, 60, 90, 120, 180 minutes after drug administration. Method of measurement: After measuring systolic and diastolic blood pressure its measured with the sum of twice the diastolic blood pressure and systolic blood pressure divided by three (3 / (2DBP + SBP)) will be calculated.;Heart Rate. Timepoint: 10, 20, 30, 45, 60, 90, 120, 180 minutes after drug administration. Method of measurement: It will be obtained by counting the number of pulses per minute. | — |
Secondary
| Measure | Time frame |
|---|---|
| Satisfaction rate. Timepoint: At intervals and ends of measurements. Method of measurement: Questionnaire.;Drug side effects. Timepoint: At intervals and ends of measurements. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNasrin Razavianzadeh
Islamic Azad University
Outcome results
None listed