Investigating the Effect of Crocin and Risperidone on Symptoms of Withdrawal Syndrome

Evaluation of the Effects of Crocin and Risperidone Separately and Synergistically on the Improvement of Pain Syndrome and Anxiety Caused by Addiction Withdrawal

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200721048159N9

Enrollment

100

Registered

2025-01-02

Start date

2025-01-20

Completion date

Unknown

Last updated

2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety and pain caused by drug withdrawal in addicted patients. Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances

Interventions

Intervention 1: Control group: Patients receiving routine treatment according to the opinion of a psychiatrist. Intervention 2: Intervention group 1 : Patients who, in addition to receiving standard t

Eligibility

Sex/Gender

Male

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Confirmed diagnosis of opioids and stimulants substances Men over 18 years old The emergence of withdrawal syndrome based on the diagnosis of a psychiatrist A score of at least 3 in the VAS test Performing a TLC test to detect consumption (methadone, morphine, amphetamine and etc..) Consent to participating in the study

Exclusion criteria

Exclusion criteria: Liver or kidney failure History of hypersensitivity to resperidone or crocin

Design outcomes

Primary

Measure	Time frame
Pain caused by drug withdrawal according to VAS test. Timepoint: Before the start of the intervention and daily for ten days after the start of the intervention. Method of measurement: Test VAS.;Examining anxiety caused by quitting addiction. Timepoint: Before the start of the intervention and daily for ten days after the start of the intervention. Method of measurement: Beck's anxiety questionnaire.	—

Measure

Time frame

Pain caused by drug withdrawal according to VAS test. Timepoint: Before the start of the intervention and daily for ten days after the start of the intervention. Method of measurement: Test VAS.;Examining anxiety caused by quitting addiction. Timepoint: Before the start of the intervention and daily for ten days after the start of the intervention. Method of measurement: Beck's anxiety questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactForouzan Ahmadpour

Khoram-Abad University of Medical Sciences

ahmadpourforoz@yahoo.com+98 66 3330 0661

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026