contrast induced acute kidney Injury. Other acute kidney failure
Conditions
Interventions
Intervention 1: Control group: normal saline 1ml/kg from 6 hours before to 6 hours after administration of contrast agent. Intervention 2: Intervention group: normal saline 1ml/kg from 6 hours before
Sponsors
Vice Chancellor for Research and Technology of Lorestan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: patient consent to enter to the study being candidate for angiography being over 18 years old systolic pressure of greater than 90 mm Hg
Exclusion criteria
Exclusion criteria: patient's tendency to exit from the study having Anaphylactic and anaphylactoid reactions during contrast media administration consumption of common antioxidant medicines in less than one week before use of contrast media and angiography consumption of nephrotoxic medicines (aminoglycosides, vancomycin and others) in less than one week before use of contrast media and angiography unstable kidney status or need of kidney transplantation impossibility of intravenous hydration for the patient consumption of Warfarin pregnancy and breastfeeding history of hypersensitivity to saffron history of hypersensitivity to contrast media participate in other clinical trials that their results may confound this intervention at least for a 28 days period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine. Timepoint: before getting medical regime and 24 and 48 hours after getting contrast media. Method of measurement: patient's medical file.;Blood urea nitrogen. Timepoint: Before getting medical regime and 24 and 48 hours after getting contrast media. Method of measurement: Laboratory kit.;Superoxide dismutase. Timepoint: Zero hours before getting medical regime of study and 4 hours after getting contrast media. Method of measurement: Laboratory kit.;Malondialdehyde. Timepoint: Zero hours before getting medical regime of study and 4 hours after getting contrast media. Method of measurement: Laboratory kit.;Catalase. Timepoint: Zero hours before getting medical regime of study and 4 hours after getting contrast media. Method of measurement: Laboratory kit.;Glutathione proxidase. Timepoint: Zero hours before getting medical regime of study and 4 hours after getting contrast media. Method of measurement: Laboratory kit.;Reactive oxygen species. Timepoint: Zero hours before getting medical regime of study and 4 hours after getting contrast media. Method of measurement: Laboratory kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactForouzan Ahmadpour
Khoram-Abad University of Medical Sciences
Outcome results
None listed