covid 19. COVID-19, virus identified
Conditions
Interventions
Intervention 1: Intervention group: Pentoxifylline group receiving 400 mg every 12 hours (Amin Pharmaceutical Company) plus colchicine half a mg every day (Mofid Pharma Pharmaceutical Company) orally
Sponsors
Vice Chancellor for Research and Technology of Lorestan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: Hospitalized patients suspected to Covid19 infection SpO2 less than 93% The presence of respiratory symptoms (including shortness of breath, pain and pressure in the chest) older than 40 years
Exclusion criteria
Exclusion criteria: Active peptic ulcer Pregnancy and lactation History of colchicine or pentoxifylline allergy Concomitant use of protease inhibitors, strong inhibitors or inducers of CYP3A4 or pgp drugs, statin other than rosuvastatin Occurrence of side effects Fauvism History of alcohol use Retinopathy Neuromuscular disease Severe renal failure and GFR less than 30 ml/min Severe hepatic impairment (bilirubin higher than 2 mg/dL and albumin less than 2.8 g/dL) Active bleeding including intracerebral hemorrhage or retinal hemorrhage Chronic diarrhea or malabsorption History of heart disease (heart failure, ventricular arrhythmia, right or left heart block, QTc more than 480 milliseconds) Dissatisfaction with the company
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of hospitalization. Timepoint: 7 -14 days. Method of measurement: Based on patient file information. | — |
Secondary
| Measure | Time frame |
|---|---|
| The duration of recovery or the duration of entry into the disease stage. Timepoint: 7-14 days. Method of measurement: Based on patient file information.;Survival rate of 28 days from the time of hospitalization. Timepoint: 28 days after starting the study. Method of measurement: Interview with the patient or her family.;The amount of arterial oxygen saturation. Timepoint: Daily. Method of measurement: Using a device to measure the percentage of oxygen saturation.;Frequency of transfer to intensive care unit. Timepoint: Daily. Method of measurement: Under supervision. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactForouzan Ahmadpour
Khoram-Abad University of Medical Sciences
Outcome results
None listed