The efficacy of oral doxycycline with Bevacizumab in diabetes

The efficacy of using oral doxycycline with intravitreal Bevacizumab injection in diabetic patients with clinically significant macular edema

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200720048150N1

Enrollment

Registered

2020-10-28

Start date

2018-10-23

Completion date

Unknown

Last updated

2020-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Diabetes, Clinically significant macular edema. Condition 2: Diabetes, Clinically significant macular edema. Type 2 diabetes mellitus with ophthalmic complications Type 1 diabetes mellitus with ophthalmic complications

Interventions

Intervention 1: Intervention group: patients received 1.25 mg IV injection of bevacizumab (Avastin, Genetech Co, San Francisco, USA) along with oral doxycycline (200 mg per day) (Hakim Pharmaceutical

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Diabetic patients with confirmed Clinically Significant Macular Edema

Exclusion criteria

Exclusion criteria: Patients with previous history of surgery for retinal detachment Patients with glaucoma Patients with uveitis Patients with macular geographic atrophy Patients with macular scar Patients with gastrointestinal distress

Design outcomes

Primary

Measure	Time frame
Central macular thickness. Timepoint: Before intervention and 2, 4, 6 and 9 months after intervention. Method of measurement: Optical Coherence Tomography images were generated using the Fast Macular Thickness Scan consisting of six radial scans oriented 30 degrees from one another, each having a 2?mm axial depth and 6?mm transverse length. Each image had 10?µm axial and 20?µm transverse resolutions in tissue and consisted of 1024 axial pixels by 512 transverse pixels with a maximum scan velocity of 400 axial per second.	—

Measure

Time frame

Central macular thickness. Timepoint: Before intervention and 2, 4, 6 and 9 months after intervention. Method of measurement: Optical Coherence Tomography images were generated using the Fast Macular Thickness Scan consisting of six radial scans oriented 30 degrees from one another, each having a 2?mm axial depth and 6?mm transverse length. Each image had 10?µm axial and 20?µm transverse resolutions in tissue and consisted of 1024 axial pixels by 512 transverse pixels with a maximum scan velocity of 400 axial per second.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Kasiri

Ahvaz University of Medical Sciences

Kasiri-a@ajums.ac.ir0098 33339196

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026