The effect of transcranial direct current stimulation (tDCS) and omega-3 supplementation on depression and weight

Determining the effectiveness of transcranial direct current stimulation (tDCS) and omega-3 supplementation on executive functions, food craving, and depressive symptoms in patients with depression and overweight

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200716048117N1

Enrollment

100

Registered

2020-10-18

Start date

2019-12-06

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: mild Depression. Condition 2: Moderate depression. Condition 3: Obesity. Major depressive disorder, single episode, mild Major depressive disorder, single episode, moderate Obesity due to excess calories

Interventions

Intervention 1: Intervention group 1: 3 sessions of transcranial direct current stimulation (tDCS), one session per week, 4 sessions of stimulation for 15 minutes each time, and omega-3 supplement (

Eligibility

Sex/Gender

Female

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Women with depression (Beck depression score above 14) overweight or obesity (BMI=25) 18 to 60 years old

Exclusion criteria

Exclusion criteria: Reluctance and satisfaction to participate in the study during pregnancy or lactation Other major psychiatric illnesses such as bipolar depression, Schizophrenia, neurological diseases such as epilepsy History of major head trauma and neurofeedback in the last two months

Design outcomes

Primary

Measure	Time frame
Depression score 14 and above in Beck questionnaire. Timepoint: Measurement of depression at the beginning of the study (before the intervention), and 14 and 28 days after receiving brain stimulation and omega-3 intake. Method of measurement: Beck Depression Inventory.	—

Secondary

Measure	Time frame
Scores of executive functions of individuals in Simple Strop computer software and Wisconsin card computer test. Timepoint: Measurement of executive functions at the beginning of the study (before the intervention), and 14 and 28 days after receiving brain stimulation and omega-3 intake. Method of measurement: Simple Strop computer software and Wisconsin card computer test.;Individual cravings score in the Summary Food Trait Questionnaire (FCQ-T). Timepoint: Measurement of food craving at the beginning of the study (before the intervention), and 14 and 28 days after receiving brain stimulation and omega-3 intake. Method of measurement: Summary Food Trait Questionnaire (FCQ-T).;People weigh in kilograms and their fat percentage with a pneumatic fat analyzer _ Model BF 511. Timepoint: Measurement of weight and fat percentage at the beginning of the study (before the intervention), and 14 and 28 days after receiving brain stimulation and omega-3 intake. Method of measurement: People weigh in kilograms and their fat percentage with a pneumatic fat analyzer _ Model BF 511.;Appetite score in a simple appetite questionnaire SNAQ. Timepoint: Measurement of appetite at the beginning of the study (before the intervention), and 14 and 28 days after receiving brain stimulation and omega-3 intake. Method of measurement: Simple appetite questionnaire SNAQ.	—

Measure

Time frame

Scores of executive functions of individuals in Simple Strop computer software and Wisconsin card computer test. Timepoint: Measurement of executive functions at the beginning of the study (before the intervention), and 14 and 28 days after receiving brain stimulation and omega-3 intake. Method of measurement: Simple Strop computer software and Wisconsin card computer test.;Individual cravings score in the Summary Food Trait Questionnaire (FCQ-T). Timepoint: Measurement of food craving at the beginning of the study (before the intervention), and 14 and 28 days after receiving brain stimulation and omega-3 intake. Method of measurement: Summary Food Trait Questionnaire (FCQ-T).;People weigh in kilograms and their fat percentage with a pneumatic fat analyzer _ Model BF 511. Timepoint: Measurement of weight and fat percentage at the beginning of the study (before the intervention), and 14 and 28 days after receiving brain stimulation and omega-3 intake. Method of measurement: People weigh in kilograms and their fat percentage with a pneumatic fat analyzer _ Model BF 511.;Appetite score in a simple appetite questionnaire SNAQ. Timepoint: Measurement of appetite at the beginning of the study (before the intervention), and 14 and 28 days after receiving brain stimulation and omega-3 intake. Method of measurement: Simple appetite questionnaire SNAQ.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahla Tabasi

Tehran University of Medical Sciences

mahla.tabasi93@gmail.com+98 21 5541 3540

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026