Vitamin D supplementation and insulin homeostasis among healthy overweight and obese adults.

The Effect of the Vitamin D Supplementation in Obese and Non-Diabetic Individuals; a Double Blind Randomized Clinical Trial.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200713048089N1

Enrollment

Registered

2020-07-15

Start date

2020-07-22

Completion date

Unknown

Last updated

2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes mellitus? Vitamin D deficiency. Diabetes mellitus due to underlying condition

Interventions

Intervention 1: Intervention group: The participants in vitamin D group will receive a 50000 IU pearl of vitamin D per week for 8 weeks. The participants are recommended to not change their overall ro

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 65 years Body Mass Index (BMI) = 25 kg/m2 Serum level of vitamin D < 30 mg/dl

Exclusion criteria

Exclusion criteria: Any history of diabetes mellitus, thyroid disorders, gastrointestinal disorders, chronic inflammatory diseases, malignancy, kidney stones, cardiovascular events Taking of drugs which have effects on calcium and phosphorus hemostasis including corticosteroids, thyroxine, warfarin, bisphosphonates, thiazides and vitamin D pregnant or lactating women are not allowed to participate in the study

Design outcomes

Primary

Measure	Time frame
Serum level of vitamin D. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Serum level of vitamin D will measure using HPLC method with Aglient device.;?Fasting insulin. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Serum level of fasting insulin will measure using ELISA method with Monobind laboratory kit.;Homeostasis Model Assessment 2 for insulin resistance. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: l of Homeostasis Model assessment will measure using HOMA2 calculator (www.dtu.ox.ac.uk/homacalculator).;Homeostasis Model Assessment 2 for ß-cell function. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: l of Homeostasis Model assessment will measure using HOMA2 calculator (www.dtu.ox.ac.uk/homacalculator).;Homeostasis Model Assessment 2 for insulin sensitivity. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: l of Homeostasis Model assessment will measure using HOMA2 calculator (www.dtu.ox.ac.uk/homacalculator).	—

Measure

Time frame

Serum level of vitamin D. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Serum level of vitamin D will measure using HPLC method with Aglient device.;?Fasting insulin. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: Serum level of fasting insulin will measure using ELISA method with Monobind laboratory kit.;Homeostasis Model Assessment 2 for insulin resistance. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: l of Homeostasis Model assessment will measure using HOMA2 calculator (www.dtu.ox.ac.uk/homacalculator).;Homeostasis Model Assessment 2 for ß-cell function. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: l of Homeostasis Model assessment will measure using HOMA2 calculator (www.dtu.ox.ac.uk/homacalculator).;Homeostasis Model Assessment 2 for insulin sensitivity. Timepoint: Before intervention and 8 weeks after intervention. Method of measurement: l of Homeostasis Model assessment will measure using HOMA2 calculator (www.dtu.ox.ac.uk/homacalculator).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSeyed Alireza Ebadi

Shahid Beheshti University of Medical Sciences

sa.ebadi@sbmu.ac.ir+98 21 7797 6409

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026