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Investigating the Effect of the Bromelain on Edema after rhinoplasty

Investigating the Effect of the Bromelain on Edema and Pain after Septorhinoplasty Surgery Compared to the Control Group - A Randomized Placebo-Controlled Trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200708048051N4
Enrollment
140
Registered
2026-04-28
Start date
2025-10-23
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rhinoplasty, edema, pain and swelling after septorhinoplasty surgery. Encounter for cosmetic surgery

Interventions

Intervention 1: Intervention group: Patients aged 18-45 years who are candidates for primary septorhinoplasty are being evaluated for the effectiveness of the drug bromelain, brand name Brozyme Ultra,

Sponsors

Rasht University of Medical Sciences
Lead Sponsor
Techra Pharmed
Collaborator

Eligibility

Sex/Gender
All
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Patients in the age group of 18-45 years candidates for primary open septorhinoplasty surgery

Exclusion criteria

Exclusion criteria: pregnancy Kidney , liver disease Hypertension Bleeding disorders Corticosteroid use for more than a week Roaccutane use Patients who experienced any complications from this drug

Design outcomes

Primary

MeasureTime frame
Edema based on the thickness of the nasal skin. Timepoint: Assessments are performed before the intervention and before surgery (baseline), and then 4 weeks after the intervention. Method of measurement: Edema measurement criteria based on ultrasound ( GE Voluson E6 ).;Ecchymosis. Timepoint: Ecchymosis assessment will be performed at weeks 1, 2, and 3 after the intervention. Method of measurement: Ecchymosis is assessed using the Ecchymosis Grading Scale, a clinical scoring scale that grades the severity of bruising around the eyes based on the extent and intensity of the discoloration.;Pain. Timepoint: Pain is assessed in the first 24 hours after surgery and then at weeks 1 and 2 after the intervention. Method of measurement: Assessment with the Visual Analogue Scale from 0-10 based on patient report.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaliheh Akbarpour

Rasht University of Medical Sciences

akbarpour_malihe@yahoo.com+98 911 325 9841

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026