Evaluation of the effects of intranasal desmopressin on intraoperative blood loss and quality of the surgical field during functional endoscopic sinus surgery

Clinical Trial of Evaluation of the effects of intranasal desmopressin on intraoperative blood loss and quality of the surgical field during functional endoscopic sinus surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200708048051N2

Enrollment

120

Registered

2021-02-12

Start date

2021-02-19

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic rhinosinusitis. Chronic sinusitis

Interventions

Intervention 1: Intervention group 1: Topical desmopressin spray, one puff in each nostril (equivalent to 20 micrograms) one hour before surgery. Intervention 2: Intervention group 2: Topical desmopre

Eligibility

Sex/Gender

All

Age

18 Years to 55 Years

Inclusion criteria

Inclusion criteria: all patients with chronic rhino-sinusitis with or without nasal polyps candidate for functional endoscopic sinus surgery

Exclusion criteria

Exclusion criteria: patients with abnormal coagulation tests patients with history of cardiovascular disease patients with coagulopathy anticoagulant drug users patients with cerebrovascular disease patients with sinonasal tumors pregnant women herbal or vitamin E drug users sinus revision surgery corticosteroid drug users diuretic drug users patients with high systemic blood pressure

Design outcomes

Primary

Measure	Time frame
Quality of the surgical field during surgery. Timepoint: during surgery. Method of measurement: The quality of the surgical field is determined by the surgeon during the operation according to the BOEZAART criteria.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaliheh Akbarpour

Rasht University of Medical Sciences

akbarpour_malihe@yahoo.com+98 13 3323 8306

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026