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Vital sign changes in use of prilocaine and mepivacaine

Hemodynamic changes (heart rate, blood pressure and oxygen saturation) comparing mepivacaine Hcl 3% with perilocaine 3%+ felypressin in controlled hypertensive patients after infra-alveolar block.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200707048045N1
Enrollment
32
Registered
2020-09-03
Start date
2020-06-22
Completion date
Unknown
Last updated
2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

controlled hypertensive patients.

Interventions

Intervention 1: Intervention group: 16 patients with injection of perilocain 3%+ felypressin daru pakhsh. Intervention 2: Intervention group: 16 patients with mepivacain hydrochlorid 3% eksir.

Sponsors

Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with controlled hypertension who are willing to cooperate

Exclusion criteria

Exclusion criteria: Patients with a history of drug allergy, a history of asthma, nasal polyps, bronchospasm or angioedema, heart failure or liver failure, pregnancy, patients with idiopathic or congenital methemoglobinemia, patients with bleeding disorders, patients taking anticoagulant drugs failure to sign a written consent

Design outcomes

Primary

MeasureTime frame
Heart rate. Timepoint: Before intervention and 10 , 30 minute after. Method of measurement: Pulse oximeter.;Blood pressure. Timepoint: Before intervention and 10 , 30 minute after. Method of measurement: Blood pressure monitor.;Blood oxygen saturation. Timepoint: Before intervention and 10 , 30 minute after. Method of measurement: Pulse oximeter.

Secondary

MeasureTime frame
Stress score. Timepoint: before and after intervention. Method of measurement: questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAhmad Homayoun

Shiraz University of Medical Sciences

ahmad.homayoun9@gmail.com+98 71 3228 4031

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026