Evaluation of vasodilatory changes and exercise performance to caffeine-beet juice supplementation in runners

The effect of short-term supplementation of caffeine and beet juice with high, low dose and placebo on vasodilator indices and athletic performance in elite runners

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200707048041N1

Enrollment

Registered

2020-08-23

Start date

2020-02-24

Completion date

Unknown

Last updated

2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Changes in nitrite, collagen 18, nitrous oxide, endothelin-1, systolic blood pressure, diastolic blood pressure and heart rate in professional runners due to caffeine-beet juice supplementation.

Interventions

Intervention 1: IIntervention and control group 1: High dose of combined supplement (9.6 mmol nitrate in beet juice made by Sensei Pharmaceutical Company and 400 mg of caffeine made by Karen Pharmaceu

Eligibility

Sex/Gender

Male

Age

18 Years to 30 Years

Inclusion criteria

Inclusion criteria: No history of metabolic disease No history of smoking Intolerance to beet juice, caffeine or other natural stimulants Do not use the drug during the research period Young elite male runners Ability to perform aerobic activity

Exclusion criteria

Exclusion criteria: Having metabolic diseases such as heart disease and hypertension History of drug use History of tobacco use Having an intolerance to caffeine Having an intolerance to beet-root juice Non-runner Female gender

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: The first and seventh days before and after two 5 km, which lasts a total of 14 days for each stage of the intervention. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Holter.;Systolic blood pressure. Timepoint: The first and seventh days before and after two 5 km, which lasts a total of 14 days for each stage of the intervention. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Mercury barometer.;Diastolic blood pressure. Timepoint: The first and seventh days before and after two 5 km, which lasts a total of 14 days for each stage of the intervention. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Mercury barometer.;Nitrate. Timepoint: The first, second, seventh and eighth days of the intervention in the first phase of the intervention, which lasts a total of 14 days. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Blood sampling.;Nitric oxide. Timepoint: The first, second, seventh and eighth days of the intervention in the first phase of the intervention, which lasts a total of 14 days. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Blood sampling.;Collagen 18. Timepoint: The first, second, seventh and eighth days of the intervention in the first phase of the intervention, which lasts a total of 14 days. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Blood sampling.;Endothelin 1. Timepoint: The first, second, seventh and eighth days of the intervention in the first phase of the intervention, which lasts a total of 14 days. This protocol is repeated in three stages and the consumption o	—

Measure

Time frame

Heart rate. Timepoint: The first and seventh days before and after two 5 km, which lasts a total of 14 days for each stage of the intervention. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Holter.;Systolic blood pressure. Timepoint: The first and seventh days before and after two 5 km, which lasts a total of 14 days for each stage of the intervention. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Mercury barometer.;Diastolic blood pressure. Timepoint: The first and seventh days before and after two 5 km, which lasts a total of 14 days for each stage of the intervention. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Mercury barometer.;Nitrate. Timepoint: The first, second, seventh and eighth days of the intervention in the first phase of the intervention, which lasts a total of 14 days. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Blood sampling.;Nitric oxide. Timepoint: The first, second, seventh and eighth days of the intervention in the first phase of the intervention, which lasts a total of 14 days. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Blood sampling.;Collagen 18. Timepoint: The first, second, seventh and eighth days of the intervention in the first phase of the intervention, which lasts a total of 14 days. This protocol is repeated in three stages and the consumption of supplements and subjects is changed. Method of measurement: Blood sampling.;Endothelin 1. Timepoint: The first, second, seventh and eighth days of the intervention in the first phase of the intervention, which lasts a total of 14 days. This protocol is repeated in three stages and the consumption o

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactHadi Atarod

Islamic Azad University

atarodsportnutrition@gmail.com+98 21 2621 6193

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026