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Evaluation the effect of Pentoxifylline on spermatozoa of Azoospermic patients

Comparison of the effect of pentoxifylline on sperm structure ,embryo morphokinetics resulting from these sperms and clinical outcomes compared to the control group in azoospermic patients

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200705048020N1
Enrollment
40
Registered
2020-09-07
Start date
2021-02-26
Completion date
Unknown
Last updated
2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

azoospermia. Male infertility

Interventions

Intervention 1: Intervention group: Addition of 3.6 mmol pentoxifylline to a drop of containing sperm sample and selection of motile sperm. Intervention 2: Control group: No intervention is made.

Sponsors

Yazd University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: All non obstructive azoospermia patients less than 50 years old and more than 50 number sperm women less than 40 years old without any Infertility problems

Exclusion criteria

Exclusion criteria: HIV- positive patient with any pathology Patients with very low sperm count women more than 40 years old Couples who also have problems with female infertility

Design outcomes

Primary

MeasureTime frame
Fertilization rate. Timepoint: One day after assisted artificial insemination. Method of measurement: formation of 2 pronucleous.;Embryo formation rate. Timepoint: 3 days after assisting artificial insemination. Method of measurement: 8 cell embryo formation.;Embryo morphokinetic rate. Timepoint: From the time of pronucleous formation until the time of embryo transfer to the mother's uterus. Method of measurement: Time Lapse Incubator.;Chemical pregnancy rate. Timepoint: One week after the embryo transfer to the uterus. Method of measurement: Blood ßHCG Measurement.

Secondary

MeasureTime frame
Clinical pregnancy rate. Timepoint: 7 weeks after embryo transfer to the uterus. Method of measurement: Assessment of cardiovascular formation using ultrasound examination.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactmohammad ali khalili

Yazd University of Medical Sciences

khalili59@hotmail.com+98 35 3824 8119

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026