Investigation of the effect of local anesthesia with epinephrine on blood pressure of people applying for tooth extraction

Investigation of the effect of local anesthesia with epinephrine (with Inferior Alveolar Nerve Block anesthesia technique) on blood pressure of people applying for tooth extraction

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200705048014N1

Enrollment

Registered

2020-08-21

Start date

2019-09-23

Completion date

Unknown

Last updated

2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blood-pressure. Elevated blood-pressure reading, without diagnosis of hypertension

Interventions

Intervention 1: Intervention group: Patients in this group were injected with two carpools of lidocaine containing 108 mg of lidocaine and 0.054 mg of epinephrine for local anesthesia. Intervention 2:

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who have referred for tooth extraction and use Inferior Alveolar Nerve Block anesthesia for anesthesia Patients who have no systemic problems and are in good general health.

Exclusion criteria

Exclusion criteria: Patients who do not want to cooperate. Patients with cardiovascular problems. Patients with uncontrolled blood pressure. Patients with uncontrolled hyperthyroidism.

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: Heart rate is measured in four stages. 1- Five minutes before the anesthetic injection. 2- Immediately after anesthesia injection. 3- Immediately after the tooth is removed. 4- Five minutes after the tooth is removed. Method of measurement: Heart rate is measured in each patient at all four stages by a dentist who does not know the type of anesthesia using an EmSig stethoscope.;Systolic blood pressure. Timepoint: Systolic blood pressure is measured in four stages. 1- Five minutes before the anesthetic injection. 2- Immediately after anesthesia injection. 3- Immediately after the tooth is removed. 4- Five minutes after the tooth is removed. Method of measurement: Systolic blood pressure is measured in each patient at all four stages by a dentist who does not know the type of anesthesia using a calibrated EmSig sphygmomanometer.;Diastolic blood pressure. Timepoint: Diastolic blood pressure is measured in four stages. 1- Five minutes before the anesthetic injection. 2- Immediately after anesthesia injection. 3- Immediately after the tooth is removed. 4- Five minutes after the tooth is removed. Method of measurement: Diastolic blood pressure is measured in each patient at all four stages by a dentist who does not know the type of anesthesia using a calibrated EmSig sphygmomanometer.	—

Measure

Time frame

Heart rate. Timepoint: Heart rate is measured in four stages. 1- Five minutes before the anesthetic injection. 2- Immediately after anesthesia injection. 3- Immediately after the tooth is removed. 4- Five minutes after the tooth is removed. Method of measurement: Heart rate is measured in each patient at all four stages by a dentist who does not know the type of anesthesia using an EmSig stethoscope.;Systolic blood pressure. Timepoint: Systolic blood pressure is measured in four stages. 1- Five minutes before the anesthetic injection. 2- Immediately after anesthesia injection. 3- Immediately after the tooth is removed. 4- Five minutes after the tooth is removed. Method of measurement: Systolic blood pressure is measured in each patient at all four stages by a dentist who does not know the type of anesthesia using a calibrated EmSig sphygmomanometer.;Diastolic blood pressure. Timepoint: Diastolic blood pressure is measured in four stages. 1- Five minutes before the anesthetic injection. 2- Immediately after anesthesia injection. 3- Immediately after the tooth is removed. 4- Five minutes after the tooth is removed. Method of measurement: Diastolic blood pressure is measured in each patient at all four stages by a dentist who does not know the type of anesthesia using a calibrated EmSig sphygmomanometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Moaddeli

Bandare-abbas University of Medical Sciences

m.moaddeli@hums.ac.ir+98 76 3335 0458

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026