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The effect of Pentoxifylline in patients with Covid-19

Evaluation of the effects of Pentoxifylline in improving the condition of patients with Covid-19

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200705048013N1
Enrollment
150
Registered
2020-07-19
Start date
2020-02-20
Completion date
Unknown
Last updated
2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19, virus identified

Interventions

Intervention 1: Intervention group: Pentoxifylline with a dose of 400 mg, made by Farabi Pharmaceutical Company, Iran, was prescribed to patients weighing less than 70 kg every 12 hours and to patient

Sponsors

Karaj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to No maximum

Inclusion criteria

Inclusion criteria: Clinical signs of fever (above 38.3 °C), dyspnea and cough Definite diagnosis of of Covid-19 based on RT-PCR

Exclusion criteria

Exclusion criteria: Diabetes Chronic cardiovascular disease Obesity (with BMI higher than 30 kg/m2) Cancer Chronic kidney disease End-stage renal disease with hemodialysis

Design outcomes

Primary

MeasureTime frame
Oxygen saturation of arterial blood. Timepoint: Before intervention, daily after intervention. Method of measurement: Pulse-oximeter monitoring.

Secondary

MeasureTime frame
Mortality. Timepoint: 7, 14, 21 and 28 days after intervention. Method of measurement: Clinical examination by physician and confirmation of death.;Refer to the intensive care unit. Timepoint: 7, 14, 21 and 28 days after intervention. Method of measurement: Clinical Frailty Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSajjad Pourasghary

Oroumia University of Medical Sciences

pourasghary.s@umsu.ac.ir+98 41 3667 0577

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026