medical Abortion. Missed abortion
Conditions
Interventions
Intervention 1: Intervention group: Receptors of misoprostol and letrozole/). group A members will receive up to 10 mg letrozole (2.5 mg letrax tablets, made by Abu Reihan Pharmaceuticals [Iran]) on d
Sponsors
Gorgan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Pregnant women candidates for termination of pregnancy under 18 weeks of gestation Missed abortions Legal and medical abortions Single pregnancy Hemoglobin level> 10 g/ l There should be no history or evidence of adrenal pathology, malignancies, porphyria, thromboembolism, severe or recurrent liver disease, or gestational pruritus Being consent to participate in the study
Exclusion criteria
Exclusion criteria: Any sensitivity to misoprostol and letrozole Having an intrauterine device Having a history of more than 2 cesarean sections Any abnormalities in pre-treatment blood tests, including CBC, liver and abnormalities in kidney function tests, including blood urea, creatinine, albumin, globulin, liver enzymes, and electrolytes Specific medical conditions such as severe anemia, coagulation disorders, active liver disease, cardiovascular disease, glaucoma, and uncontrolled seizure disorders Having a history of thromboembolism, adrenal diseases, steroid-dependent cancer, porphyria, and disorders that require treatment with glucocorticoids, such as bronchial asthma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of induction of successful fetal abortion with transvaginal ultrasound. Timepoint: group A members will receive up to 10 mg letrozole (2.5 mg letrax tablets, made by Abu Reihan Pharmaceuticals [Iran]) on days 1 to 3. Group B members will also receive placebo tablets, similar in appearance and taste to letrozole tablets , on days 1 to 3 .finally all patients will undergo transvaginal ultrasound on the fifth day after medical therapy. Method of measurement: Transvaginal ultrasound for successful abortion and BHCG check. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side Effects of Misoprostol. Timepoint: During the study, blood pressure, heart rate and patient temperature will be checked every four hours by the ward nurse and side effects including fever (body temperature more than 38 degrees of Celsius), sweating, hot flashes, arthralgia and fatigue, nausea, vomiting, bone pain, dizziness, muscle aches, diarrhea, abdominal pain, stomach pain, vaginal bleeding, sore throat, pain when urinating, difficulty in urinating, cough, rash, flu-like symptoms, difficulty in sleeping or in staying asleep, amount of bleeding, and the time of discarding of the residual tissue will be recorded by the resident and these data will be written in the patient's dossier. Method of measurement: Measuring fever with a thermometer and measuring blood pressure with a cuff pressure gauge, clinical examinations and a history of the patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Moghadase Jahanshahi
Gorgan University of Medical Sciences
Outcome results
None listed