Effect of oral colchicine on urethral dilation control

A clinical trial to compare the effectiveness of oral colchicine and placebo on the need for urethral dilation after internal urethrotomy

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200628047937N1

Enrollment

176

Registered

2020-08-12

Start date

2020-08-22

Completion date

Unknown

Last updated

2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urethral dilation. Other specified disorders of urethra

Interventions

Intervention 1: Intervention group: The intervention group will receive 1 mg oral colchicine after internal urethrotomy for 6 weeks. Intervention 2: Control group: The control group will receive 1 mg

Eligibility

Sex/Gender

Male

Age

20 Years to No maximum

Inclusion criteria

Inclusion criteria: Narrowing shorter than 1 centimeter in bulbar urethral stricture Single urethral strictures First-time visitor Age over 20 years

Exclusion criteria

Exclusion criteria: Sensitivity to colchicine Having gastrointestinal problems The history of liver failure The history of renal disease

Design outcomes

Secondary

Measure	Time frame
The rate of pain. Timepoint: 6 weeks and 3 months after intervention. Method of measurement: Analogue Scale for Pain (VAS).	—

Primary

Measure	Time frame
Urethral stricture. Timepoint: 6 weeks and 3 months after intervention. Method of measurement: Retrograde urethrography.;Symptoms of acute urinary. Timepoint: 6 weeks and 3 months after intervention. Method of measurement: Clinical urine tests.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSamane Shirzadi

Mashhad University of Medical Sciences

Shirzadi.samane73@gmail.com+98 51 3760 4106

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026