Investigation of the effect of metformin gel on severe chronic periodontitis

Comparison of the therapeutic effect of metformin gel in patients with severe chronic periodontitis and control group

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200623047900N1

Enrollment

Registered

2020-06-29

Start date

2020-07-22

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: Intervention group: Use of 1% metformin gel. Intervention 2: Control group: Using a placebo.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Conscious consent of the patient to participate in the research The depth of the periodontal pocket is greater than or equal to 5 mm Do not consume alcohol and any tobacco Do not take antibiotics for three months before the visit No history of periodontal treatment 6 months before referral Non-consumption of systemic metformin Lack of any systemic disease that is effective in a person's periodontal condition. Not being pregnant or breastfeeding

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Clinical attachment loss. Timepoint: After 3 weeks, 2 months and 4 months after placing the drug deep in the Periodontal pocket. Method of measurement: Through a clinical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSanaz Isar

Zahedan University of Medical Sciences

Arbabi.Parvin@zaums.ac.ir+98 54 3341 5705

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026