Evaluation of intravenous vitamin C administration on methadone excretion

Evaluation of intravenous vitamin C administration on methadone excretion in methadone toxicity patients

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200621047863N1

Enrollment

Registered

2020-07-02

Start date

2020-06-21

Completion date

Unknown

Last updated

2020-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

methadone poisoning.

Interventions

Intervention 1: First intervention group: 18 patients will receive 12 g of intravenous vitamin C (in divided 3 g doses every 6 hours). Intervention 2: Second Intervention Group: 18 patients will recei

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All patients with methadone poisoning

Exclusion criteria

Exclusion criteria: History of kidney stones, hemochromatosis, G6PD deficiency, iron overload and diabetes Consumption of another substance in addition to methadone

Design outcomes

Primary

Measure	Time frame
Serum methadone levels. Timepoint: 24 hours after the first dose of vitamin C (6 hours after the last dose). Method of measurement: Laboratory measurement of serum vitamin C level and urine pH.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Sadat Hashemi

Ilam University of Medical Sciences

m.s.hashemi86@gmail.com+98 84 3222 7134

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026