The effect of esophageal pressure measurement to prevent pulmonary barotrauma in patients with Covid 19 undergoing respiratory support

Evaluation of the effect of esophageal pressure measurement for non-invasive positive pressure ventilation (NIPPV) regulation for the prevention of pulmonary barotrauma in comparison with control group in patients with Covid 19 undergoing respiratory support admitted to the intensive care unit

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200612047740N4

Enrollment

Registered

2022-06-18

Start date

2022-06-21

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19 Disease

Interventions

Intervention 1: Intervention group: Patients's nasogastric tube is pulled up and connected to a manometer and their intraesophageal pressure is measured. Ventilation settings are adjusted so that the

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with Covid 19 with positive PCR or CT scan Hospitalized in the intensive care unit Patient is receiving non-mechanical ventilation Patient should be fed through the gastric feeding tube (NG tube) Informed consent of the patient or his legal guardian

Exclusion criteria

Exclusion criteria: Coagulation disorders Gastrointestinal bleeding History of fractures and trauma to the base of the skull

Design outcomes

Primary

Measure	Time frame
Intra esophageal pressure. Timepoint: Intraesophageal pressure is measured twice daily (morning and evening) while receiving non-invasive ventilation while the patient is in the intensive care unit(ICU). Method of measurement: Manometer.;Number of people with barotrauma. Timepoint: From the start of non-invasive ventilation to the onset of barotrauma. Method of measurement: Observe and record.	—

Secondary

Measure	Time frame
Duration of stay in the intensive care unit. Timepoint: From the time of entering the intensive care unit until the time of discharge or the time of death. Method of measurement: Observe and record.;Trans pulmonary pressure. Timepoint: Trans pulmonary pressure is measured twice daily (morning and evening) while receiving non-invasive ventilation while the patient is in the ICU. Method of measurement: Manometer.;Time of barotrauma. Timepoint: Number of days from the start of non-invasive ventilation to the onset of barotrauma. Method of measurement: Observe and record.;Oxygen saturation. Timepoint: It is measured twice daily (morning and evening) while receiving non-invasive ventilation while the patient is in the intensive care unit(ICU). Method of measurement: Pulse oximeter.	—

Measure

Time frame

Duration of stay in the intensive care unit. Timepoint: From the time of entering the intensive care unit until the time of discharge or the time of death. Method of measurement: Observe and record.;Trans pulmonary pressure. Timepoint: Trans pulmonary pressure is measured twice daily (morning and evening) while receiving non-invasive ventilation while the patient is in the ICU. Method of measurement: Manometer.;Time of barotrauma. Timepoint: Number of days from the start of non-invasive ventilation to the onset of barotrauma. Method of measurement: Observe and record.;Oxygen saturation. Timepoint: It is measured twice daily (morning and evening) while receiving non-invasive ventilation while the patient is in the intensive care unit(ICU). Method of measurement: Pulse oximeter.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Naderi

Artesh University of Medical Sciences

hossein.naderi1374@gmail.com+98 21 8609 6350

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026