COVID-19. COVID-19
Conditions
Interventions
Intervention group: Plasmapheresis will be performed in 3 sessions at intervals of 24 to 36 hours based on the daily evaluation of the patient in the dialysis ward of Shahid Mohammadi Hospital in Band
Sponsors
Bandare-abbas University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: COVID-19 patients with positive Realtime PCR test for COVID-19 tachypnea> Respiratory Rate 30 per minute and dyspnea, Oxygen saturation lower than 88% and fraction of inspired oxygen/ PaO2 ratio lower to equal 300, and increased lung involvement by more than 50% on CT scan. Patient with symptoms of respiratory failure, patient in need or under mechanical ventilation, patient with multiple organ failure and patient with shock symptoms Presence of two positive inflammatory markers including: Ferritin greater than 1000 or CRP above 50 mg/dl or ' ' +++ ' ' or Lactate dehydrogenase greater than 1000 Lack of proper response to antiviral and corticosteroid therapy and hypoxia during hospitalization
Exclusion criteria
Exclusion criteria: Low blood pressure lower than normal range, which causes a further decrease in blood pressure during plasmapheresis. Coagulation disorders that cause bleeding during plasmapheresis. Decreased blood platelets below the normal range, which may increase bleeding during plasmapheresis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum IL-6 levels. Timepoint: Before plasmapheresis and after the last stage of plasmapheresis. Method of measurement: ELISA technique.;Serum IL-1ß levels. Timepoint: Before plasmapheresis and after the last stage of plasmapheresis. Method of measurement: ELISA technique.;Serum TNF-a levels. Timepoint: Before plasmapheresis and after the last stage of plasmapheresis. Method of measurement: ELISA technique.;Serum IFN-? levels. Timepoint: Before plasmapheresis and after the last stage of plasmapheresis. Method of measurement: ELISA technique.;Clinical manifestation. Timepoint: Before plasmapheresis and after the last stage of plasmapheresis. Method of measurement: Clinical examination and completion of a questionnaire.;Inflammatory factors of peripheral blood. Timepoint: Before plasmapheresis and after the last stage of plasmapheresis. Method of measurement: Peripheral blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Hassani Azad
Bandare-abbas University of Medical Sciences
Outcome results
None listed