Evaluation of the effect of high flow oxygen delivery under different temperatures in COVID-19 patients

The effectiveness of oxygen delivery through high flow nasal cannula (HFNC) with different temperatures in improving the clinical symptoms of COVID-19 patients

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200611047727N4

Enrollment

Registered

2021-04-28

Start date

2021-04-19

Completion date

Unknown

Last updated

2021-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19

Interventions

Intervention 1: First intervention group: In this group, patients undergo oxygen therapy with a high-flow device for "24 hours". This device transmits hot and humid air with high flow (up to 60 l / mi

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: New coronavirus detection (clinical or paraclinical) Oxygen saturation less than 90% Written consent to participate in the study Age over 18 years Moderate to severe Covid-19 disease is hospitalized and requires respiratory support

Exclusion criteria

Exclusion criteria: PaCO2>65 PH<7.28 Cardiovascular disorders that prevent pulmonary rehabilitation

Design outcomes

Primary

Measure	Time frame
Ferritin. Timepoint: Before starting oxygen therapy, 24 hours later, 7 days later. Method of measurement: Laboratory tests.;Oxygen saturation. Timepoint: Before starting oxygen therapy, 24 hours later. Method of measurement: Pulse oxymetry.;Partial pressure of carbon dioxide. Timepoint: Before starting oxygen therapy, 24 hours later, 7 days later. Method of measurement: VBG analysis.;Interleukin 6. Timepoint: Before starting oxygen therapy, 24 hours later, 7 days later. Method of measurement: Laboratory tests.;C-Reactive Protein. Timepoint: Before starting oxygen therapy, 24 hours later, 7 days later. Method of measurement: Laboratory tests.;Erythrocyte Sedimentation Rate. Timepoint: Before starting oxygen therapy, 24 hours later, 7 days later. Method of measurement: Laboratory tests.	—

Measure

Time frame

Ferritin. Timepoint: Before starting oxygen therapy, 24 hours later, 7 days later. Method of measurement: Laboratory tests.;Oxygen saturation. Timepoint: Before starting oxygen therapy, 24 hours later. Method of measurement: Pulse oxymetry.;Partial pressure of carbon dioxide. Timepoint: Before starting oxygen therapy, 24 hours later, 7 days later. Method of measurement: VBG analysis.;Interleukin 6. Timepoint: Before starting oxygen therapy, 24 hours later, 7 days later. Method of measurement: Laboratory tests.;C-Reactive Protein. Timepoint: Before starting oxygen therapy, 24 hours later, 7 days later. Method of measurement: Laboratory tests.;Erythrocyte Sedimentation Rate. Timepoint: Before starting oxygen therapy, 24 hours later, 7 days later. Method of measurement: Laboratory tests.

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Secondary

Measure	Time frame
Borg scale. Timepoint: Before starting oxygen therapy, every day for a week. Method of measurement: Borg questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Sadat Mirenayat

Shahid Beheshti University of Medical Sciences

mirenayat_m@yahoo.com+98 21 2610 5050

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026