The effect of zinc sulfate and folic acid on endocrine indices, CRP and lipid profile in women with polycystic ovary syndrome

The effect of zinc sulfate and folic acid on endocrine indices, CRP and lipid profile in women with polycystic ovary syndrome in 2017-18.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200610047715N1

Enrollment

Registered

2020-12-27

Start date

2017-12-01

Completion date

Unknown

Last updated

2021-01-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Polycystic ovary syndrome. Polycystic ovarian syndrome

Interventions

Intervention 1: Intervention group: The first group received 220 mg of zinc sulfate (containing 50 mg of zinc) daily for 8 weeks. Intervention 2: Intervention group: the second group received 5 mg of

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Oligoovulation or / and anovulation Clinical symptoms (Ferriman-Gallwey score=6 or Acne or Seborrhoeic) or biochemical hyperandrogenism Evidence of polycystic ovaries on ultrasound

Exclusion criteria

Exclusion criteria: Hyperprolactinoma Thyroid disease Cardiovascular diseases Kidney-liver and neoplastic diseases Type 2 diabetes Pregnancy or breastfeeding Absorption disorders Use of drugs such as anti-diabetic drugs, anti-obesity drugs, diuretics, OCP, steroid and hormonal drugs (at least 3-6 months) and drugs that interfere with folic acid (perimetamine, aspirin, carbamazepine, chloramphenicol, chlorothiazide, conjugated estrogens, forge , Hydrochlorothiazide, Methotrexate, Phenytoin, Phenobarbital, Sulfamethoxazole, Salicylate)

Design outcomes

Primary

Measure	Time frame
FBS. Timepoint: 8 weeks after taking the drug. Method of measurement: BT4500.;Dehydroepiandrosterone sulfate. Timepoint: 8 weeks after taking the drug. Method of measurement: ELISA reader.;Testosterone. Timepoint: 8 weeks after taking the drug. Method of measurement: ELISA reader.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Shafipour

Rafsanjan University of Medical Sciences

mr.shafiepour@gmail.com+98 34 3428 0000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026