Patients with severe and moderate brain injury. Diffuse traumatic brain injury
Conditions
Interventions
Intervention 1: Case group: citicoline drug at a dose of 2000 mg oral twice daily by injection for 1 week and 2000 mg twice daily orally. Intervention 2: Control group: Taking placebo.
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with severe and moderate traumatic brain injury based on GCS less than 12 Patients should be without traumatic major lesions in the thorax, abdomen, and limbs Patients without heart problems Have the satisfaction to enter the study
Exclusion criteria
Exclusion criteria: Previous history of brain Injury, stroke, or neurological disease Contraindications or sensitivity to Citicoline The presence of comorbidities such as cardiovascular, renal, hepatic, and malignant history Traumatic brain injury, major trauma to the thorax, abdomen and other organs Unstable hemodynamics Pregnancy Surgical interventions were performed within the first 24 hours after trauma cardiopulmonary resuscitation was performed within the first 24 hours after trauma Dissatisfaction of the patient to enter the study and her/his death during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improving the patient's barthel index. Timepoint: Upon arrival, one month, three months and six months. Method of measurement: Barthel Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Mahmoodkhani
Esfahan University of Medical Sciences
Outcome results
None listed