Major Depression. Major depressive disorder, recurrent
Conditions
Interventions
Intervention 1: Intervention group: Sertraline 50 mg and curcumin 1000 mg so that in the first four days of sertraline 25 mg, then 50 mg sertraline until the end of the intervention. Curcumin at a dos
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: diagnosis of major depression by psychiatrist no history of drug abuse no history of endocrinological disorders no history of immune dysfunction disorders no history of other CNS disorders not obese not being on any type of dieting no suicidal idea no psychosis not using antidepressant medications for last three months not using anti inflammatory medications not using unprescribed medicine speaking Persian fluently ability to write Persian not pregnant
Exclusion criteria
Exclusion criteria: history of drug abuse endocrinological disorders immune dysfunction disorders other CNS disorders obesity using a special form of diet suicide idea psychosis using antidepressant medications for last three months using anti inflammatory medications using unprescribed medicine pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Speed processing time in trail making task A. Timepoint: At beginning, after 6 weeks and12 weeks. Method of measurement: trail making task A.;Speed processing time in trail making task B. Timepoint: At beginning, after 6 weeks and12 weeks. Method of measurement: trail making task B.;Executive function score on verbal fluency task. Timepoint: At beginning, after 6 weeks and12 weeks. Method of measurement: verbal fluency task.;Executive function score on Wisconsin sorting test. Timepoint: At beginning, after 6 weeks and12 weeks. Method of measurement: Wisconsin sorting test.;Serum level of interleukin 1 beta. Timepoint: At the beginning and week 12. Method of measurement: Serum test, Enzyme linked Immuno Assay ,ELISA.;Serum level of interleukin 6. Timepoint: At the beginning and week 12. Method of measurement: Serum test, Enzyme linked Immuno Assay ,ELISA.;Serum level of high sensitivity C reactive protein. Timepoint: At the beginning and week 12. Method of measurement: Serum test, Enzyme linked Immuno Assay ,ELISA.;Executive function score on Tower of London Test. Timepoint: At beginning, after 6 weeks and12 weeks. Method of measurement: Tower of London Test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZeynab Ali madadi
Iran University of Medical Sciences
Outcome results
None listed