Condition 1: Bipolar disorder. Condition 2: Metabolic syndrome. Bipolar affective disorder Nutritional and metabolic disorders in diseases classified elsewhere
Conditions
Interventions
Intervention 1: Intervention group: Topiramate tablet (TOPIRAMATE-ARYA 25MG TAB) with dose 25-100mg daily, once daily orally for 3 months. Intervention 2: Control group: placebo tablet(School of Pharm
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: Consent to participate in the study by completing the informed consent form by patient and family. Lack of any chronic physical illness. Negative history of recieving any antypsychotic drug or mood stabilizers or drugs that could change appetite during recent 3 month before study Lack of history of allergic reaction to topiramate Lack of history of renal insufficiency or renal stone Age between 6-18 years
Exclusion criteria
Exclusion criteria: patient or family unwillingness to stay in study Need to ECT treatment during study Any unexpected new physical illness that could change medical care of patient
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bipolar disorder. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: Young mania rating scale.;Fasting blood glucose. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: Lab kit.;Triglyceride. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: Lab kit.;Glycated hemoglobin. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: Lab kit.;Cholestrol. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: Lab kit.;Low density lipoprotein. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: Lab kit.;High density lipoprotein. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: Lab kit.;Fasting insulin. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: Lab kit.;Blood pressure. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: sphygmomonometer.;Waist circumference. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: Standard meter.;Weight. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: Standard scale.;Height. Timepoint: Before intervention and 1,3 months after intervention. Method of measurement: Standard meter. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMostafa Haghshenas
Esfahan University of Medical Sciences
Outcome results
None listed