Effect of topical Simvastatin in treatment of Bedsore

Evaluation of the Effectiveness of topical cream 3% Simvastatin on the percentage of wound healing of grade 2 and 3 Bedsore in Diabetic and non_diabetic people compared to Placebo and Standard treatment

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200602047634N1

Enrollment

Registered

2020-06-05

Start date

2020-06-13

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bed sore.

Interventions

Intervention 1: Intervention group: Topical cream containing 3% Simvastatin, apply on clean wound Twice daily, a 50 gram cream every week, treatment for 3 weeks. Intervention 2: Control group: Topical

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who sign informed consent Patients with Diabetes Patients with grade 2 or 3 Bedsores

Exclusion criteria

Exclusion criteria: Patients with a history of allergy to Statins Patients who are pregnant or lactating

Design outcomes

Primary

Measure	Time frame
30% reduction in wound size. Timepoint: Measure the size of the wound at the beginning of the study and 7, 14 and 21 days after starting topical Simvastatin. Method of measurement: Ruler of wound.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAfarin Aghajari

Ahvaz University of Medical Sciences

afarinaghajari01@gmail.com+98 61 5235 5757

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026