The effect of painkillers on post-operative pain in gallbladder surgery.

Comparative Study of the Effect of Apotel and Ketorolac Injection on Post-operative Pain Management and Decrease in Side Effects in Patients undergoing Laparoscopic Cholecystectomy Surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200601047627N1

Enrollment

Registered

2020-06-12

Start date

2020-06-21

Completion date

Unknown

Last updated

2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholecystitis. Calculus of gallbladder with acute and chronic cholecystitis with obstruction

Interventions

Intervention 1: Intervention group: Apotel recipient, 0 and 4 hours after surgery (2 times), PRN Pethidine, Intravenous injection. Intervention 2: Intervention group: Ketorolac recipient, 0 and 4 hour

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with a history of cholecystitis Patients with biliary colic Patients with gallstone Patients with gallbladder polyp (more than 10 mm)

Exclusion criteria

Exclusion criteria: Pregnant and lactating women Patients with impaired renal or dialysis function Patients with heart disease and who should take warfarin during treatment Patients with contraindications for opioids use Patients with hemorrhage especially gastrointestinal Bleeding Patients with high blood pressure history or History of bloodshed Patients with abuse drug Patients with asthma, lung disease and allergies to NSAIDs Patients with multiple trauma. Patients with a history of psychiatric disorders or unable to communicate verbally Patients who need anti-emetic or antihistamines before or after surgery. Patients who should be treated with medication from one month before the surgery or during the study period. Patients who should be used the painkiller 7 days before the surgery. Patients who has a drain after surgery. Patients with a Body Mass Index of more than 35

Design outcomes

Primary

Measure	Time frame
Check the rate of post-operative pain in both intervention group separately. Timepoint: Instantly after surgery (Recovery - before the intervention begins) + 6, 12, 18 and 24 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Visual analogue scale : (0-10).;Check the dosages of the painkiller in both intervention group separately. Timepoint: 24 hours after surgery (Surgery wards - after the intervention). Method of measurement: Register in the checklist : Millilitre (Quantitative).;Check the prevalence rate of nausea in both intervention group separately. Timepoint: 2, 4, 8 and 12 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Visual analogue scale : (0-2).;Check the prevalence rate of vomiting in both intervention group separately. Timepoint: 2, 4, 8 and 12 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Visual analogue scale : (0-2).;Check the rate of fever in both intervention group separately. Timepoint: 2, 4, 8 and 12 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Register in the checklist : Centigrade (Quantitative).;Check the prevalence rate of gastritis in both intervention group separately. Timepoint: 2, 4, 8 and 12 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Visual analogue scale : (0-2).;Check the prevalence rate of constipation in both intervention group separately. Timepoint: 2, 4, 8 and 12 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Visual analogue scale : (0-2).	—

Measure

Time frame

Check the rate of post-operative pain in both intervention group separately. Timepoint: Instantly after surgery (Recovery - before the intervention begins) + 6, 12, 18 and 24 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Visual analogue scale : (0-10).;Check the dosages of the painkiller in both intervention group separately. Timepoint: 24 hours after surgery (Surgery wards - after the intervention). Method of measurement: Register in the checklist : Millilitre (Quantitative).;Check the prevalence rate of nausea in both intervention group separately. Timepoint: 2, 4, 8 and 12 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Visual analogue scale : (0-2).;Check the prevalence rate of vomiting in both intervention group separately. Timepoint: 2, 4, 8 and 12 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Visual analogue scale : (0-2).;Check the rate of fever in both intervention group separately. Timepoint: 2, 4, 8 and 12 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Register in the checklist : Centigrade (Quantitative).;Check the prevalence rate of gastritis in both intervention group separately. Timepoint: 2, 4, 8 and 12 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Visual analogue scale : (0-2).;Check the prevalence rate of constipation in both intervention group separately. Timepoint: 2, 4, 8 and 12 hours after surgery (Surgery wards - after the intervention begins). Method of measurement: Visual analogue scale : (0-2).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadhossein Safari

Kermanshah University of Medical Sciences

mohammadhosein.safari@kums.ac.ir+98 83 3427 6301

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026