The effect of lidocaine spray to decrease propofol dosage

Comparison of the sedation effect of propofol with lidocaine spray versus isolated propofol admission during upper GI endoscopy in elective and outpatient patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200526047573N1

Enrollment

160

Registered

2020-10-20

Start date

2020-05-20

Completion date

Unknown

Last updated

2020-11-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases of upper digestive system which need endoscopy. Gastric ulcer

Interventions

Intervention 1: propofol (Razavi Pharmacy) at a dose of 50 µg/kg. Intervention 2: propofol at a dose of 50 µg/kg and a total of 3 puffs of 10% lidocaine spray (Caspian Tamin company) to the throat and

Eligibility

Sex/Gender

All

Age

20 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patient age between 20 to 65 years old Patients requiring upper gastrointestinal endoscopy

Exclusion criteria

Exclusion criteria: Psychological disease Addiction Anemia Obesity Swallowing Disorders (Myasthenia gravis and Alzheimer's) Cardiac Disease Low blood pressure Bradycardia Hepatic Failure Kidney Disease

Design outcomes

Primary

Measure	Time frame
Propofol Dosage. Timepoint: At The End of Endoscopy. Method of measurement: Milligram per kilogram.;Nausea and Vomiting. Timepoint: At The End of Endoscopy. Method of measurement: Patient's clinical symptoms.;Respiratory Distress. Timepoint: At The End of Endoscopy. Method of measurement: Intercostal muscle retraction.;Heart Rate. Timepoint: At The End of Endoscopy. Method of measurement: Cardiac monitoring.;Blood Pressure. Timepoint: At The End of Endoscopy. Method of measurement: Non Invasive Blood Pressure Tools.	—

Measure

Time frame

Propofol Dosage. Timepoint: At The End of Endoscopy. Method of measurement: Milligram per kilogram.;Nausea and Vomiting. Timepoint: At The End of Endoscopy. Method of measurement: Patient's clinical symptoms.;Respiratory Distress. Timepoint: At The End of Endoscopy. Method of measurement: Intercostal muscle retraction.;Heart Rate. Timepoint: At The End of Endoscopy. Method of measurement: Cardiac monitoring.;Blood Pressure. Timepoint: At The End of Endoscopy. Method of measurement: Non Invasive Blood Pressure Tools.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlma Bigdeli

Babol University of Medical Sciences

dr.a.bigdeli67@gmail.com+98 11 3223 8301

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026