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Effect of Corton on olfactory dysfunction in COVID-19 patients

Effect of inhaled corticosteroids in the treatment of anosmia in patients with COVID-19

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200522047542N1
Enrollment
70
Registered
2020-08-04
Start date
2020-07-18
Completion date
Unknown
Last updated
2020-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anosmia. Anosmia

Interventions

Intervention 1: Intervention group: Inhaled Corticosteroid spray (0.05% Mometasone) twice daily for 4 weeks. Intervention 2: Control group: sodium chloride spray (0.65%) twice daily for 4 weeks.

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with COVID-19 who have been referred or admitted to Qaem, Imam Reza, or Shariati Hospital diagnosed with a protocol defined by the World Health Organization. People who have not experienced any signs of reduced sense of smell and taste for at least 2 weeks before the onset of the first manifestation of Covid-19. People who were diagnosed with hyposmia or anosmia.

Exclusion criteria

Exclusion criteria: People with certain underlying conditions (such as Parkinson's, Alzheimer's, severe nutritional disorders, acute rhinitis, acute catarrhal sinusitis, SICA syndrome (especially after radiation), nasal mucosal congestion, for example after rhinoplasty, olfactory nerve damage in trauma, etc., which are exposed to the reduction of the sense of smell independent of the coronavirus, as well as, people who experience other viral and bacterial infections simultaneously with COVID-19 People with a history of asthma and allergies are excluded Participants who refused to participate in follow-up measurements, provide data, or give consent considered withdrawn.

Design outcomes

Primary

MeasureTime frame
Smell Sense. Timepoint: Time intervals: one week, two weeks, and one month after the intervention. Method of measurement: By VAS test.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasoumeh Hosseinpour

Mashhad University of Medical Sciences

drmh2018@gmail.com+98 51 3840 9642

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026