Comparison of the effect of Hibiscus sabdariffa L. extract and thiazide on albuminuria in patients with type 2 diabetes

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200522047538N1

Enrollment

105

Registered

2022-09-26

Start date

2022-09-23

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes. Diabetes mellitus due to underlying condition with kidney complications

Interventions

Intervention 1: Intervention group: 25 mg hydrochlorothiazide tablets daily and 40 mg valsartan tablets every 12 hours. Intervention 2: Intervention group: 420 mg hibiscus tablet every 12 hours mornin

Eligibility

Sex/Gender

All

Age

40 Years to 70 Years

Inclusion criteria

Inclusion criteria: 40 to 70 years old2 Man or Non-pregnant woman Provide conscious written and verbal consent The patient should be admitted to the clinic with a diagnosis of type 2 diabetes confirmed Blood pressure above 130/80 mm Hg The person is willing and able to follow the study instructions and go to the clinic for a visit.

Exclusion criteria

Exclusion criteria: Allergic to the plant Normal blood pressure (mm HgSBP = 120; DBP = 80 mm Hg) Stage two and above Patients with renal failure, coronary artery disease, heart failure .Pregnancy Any metabolic or malabsorption disease that may interfere with the absorption of hibiscus (such as celiac disease, chronic pancreatitis, etc.). Taking psychiatric medications (mood stabilizer, antidepressant, anti-anxiety or antipsychotic)

Design outcomes

Primary

Measure	Time frame
Urinary albumin. Timepoint: Albuminuria before the intervention and 3 months later. Method of measurement: Using a 24-hour urine collection test and examining the amount of protein and albumin excretion.	—

Secondary

Measure	Time frame
Blood pressure. Timepoint: Blood pressure with a sphygmomanometer before the start of the intervention and three consecutive weeks after the start of the intervention and after the end of the intervention. Method of measurement: Blood pressure measurement is performed by an experienced and trained technician who is unaware of the intervention, in a blinded manner. According to the Kaplan protocol, the blood pressure of the patients after at least 5 minutes of rest in a sitting position for three consecutive weeks at a certain hour by It is measured by an experienced and trained technician. For this measurement, Richter's Nova model desktop mercury pressure gauge is used.	—

Measure

Time frame

Blood pressure. Timepoint: Blood pressure with a sphygmomanometer before the start of the intervention and three consecutive weeks after the start of the intervention and after the end of the intervention. Method of measurement: Blood pressure measurement is performed by an experienced and trained technician who is unaware of the intervention, in a blinded manner. According to the Kaplan protocol, the blood pressure of the patients after at least 5 minutes of rest in a sitting position for three consecutive weeks at a certain hour by It is measured by an experienced and trained technician. For this measurement, Richter's Nova model desktop mercury pressure gauge is used.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.Maryam Kiani

Gorgan University of Medical Sciences

kiani.m94@gmail.com+98 17 3432 3594

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026