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Comparison of combination therapies of COVID_19

Evaluation of the efficacy and side effects of combination therapy of Kaletra and Hydroxychloroquine in comparison with Atazanavir / Ritonavir and Hydroxychloroquine in the treatment of patients with COVID-19

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200517047485N1
Enrollment
108
Registered
2020-05-29
Start date
2020-06-20
Completion date
Unknown
Last updated
2020-06-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19, virus identified

Interventions

Intervention 1: Intervention group: Hydroxychloroquine 200 mg tablet, every 12 hours with Atazanavir / Ritonavir tablets daily for at least 5-7 days. Intervention 2: Control group: Hydroxychloroquine

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients who are hospitalized in the ward and are considered to have a moderate form of COVID-19 (need to be admitted to the ward and not ICU hospital) Patients who are satisfied with the study entry

Exclusion criteria

Exclusion criteria: The patient has a severe disease that requires Ribavirin The patient need to be hospitalized in the ICU or intubation The patient has a mild form of the disease that does not require hospitalization (patients with a history of outpatient treatment for COVID-19). Patients with specific underlying disease and / or need to take specific medications

Design outcomes

Primary

MeasureTime frame
Oxygen saturation following combination therapy for COVID-19. Timepoint: Daily examination of the patient during hospitalization. Method of measurement: pulse oxymetry.

Secondary

MeasureTime frame
Treatment outcome (recovery rate). Timepoint: At the end of treatment and hospitalization. Method of measurement: physical examination and patient file.;Mortality rate. Timepoint: At the end of treatment and hospitalization. Method of measurement: patient file.;Complications of disease. Timepoint: At the end of treatment and hospitalization. Method of measurement: physical examination and patient file.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHossein Mazaherpour

Arak University of Medical Sciences

h.mazaherpour@arakmu.ac.ir086-32222003-8

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026