Effect of Celecoxib and flouxetin combination on depression in Irritable Bowel Syndrome patients

: Effect of Celecoxib and flouxetin combination on depression in Irritable Bowel Syndrome patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20200517047476N1

Enrollment

Registered

2021-01-20

Start date

2020-07-05

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Irritable Bowel Syndrome. Condition 2: Major Depressive Disorder. Irritable bowel syndrome Major depressive disorder, single episode

Interventions

Intervention 1: Intervention group: 32 patients who receive fluoxetine and celecoxib (200 mg) capsules containing celexib in the same form as placebo 2 times a day for 6 weeks. This group also receive

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Having irritable bowel syndrome based on ROME IV criteria Beck's depressive score above 17 Clinical diagnosis of major depressive disorder

Exclusion criteria

Exclusion criteria: Age less than 18 years and over 60 years History of dementia Weight loss of more than 5% of the patient's weight in the last 6 to 12 months Hematochezia Anemia History of bleeding from gastric ulcer Gastric or peptic ulcer Inflammatory bowel disease Mental retardation Cancer

Design outcomes

Primary

Measure	Time frame
Depression score in Beck questionnaire. Timepoint: befor the trial - aftre 21 & 42 day. Method of measurement: Beck Depression Inventory.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFaeghe Seidmohamadi

Sanandaj University of Medical Sciences

Seidmohamadifaegheh@gmail.com+98 87 3522 7458

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026