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The effect of Hyoscyamus niger with propolis on covid-19

The effectiveness comparison of Hyoscyamus niger methanolic extract and propolis in the treatment of patients with covid-19

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200516047462N2
Enrollment
140
Registered
2020-07-17
Start date
2020-07-08
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronavirus. Covid-19

Interventions

Intervention 1: Intervention group: Herbal product including methanolic extract of seeds and propolis is prepared in the form of 60 cc syrup and this amount of syrup is prepared for two days of the pa

Sponsors

Kashan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Acute respiratory labeling (ARI) with 2-fold reduction under control: RR> 30; 80% <PO2 <93%; Chest floor Pulmonary infiltration; Clinical judgment of a specialist Age range 18 to 85 years of both sexes The patient does not have any serious concurrent cardiovascular and cerebral diseases The patient's ability and personal desire to fill out a personal consent form to enter the study

Exclusion criteria

Exclusion criteria: History of heart disease, mental disease and pregnant women Existence of any history of allergy to any of the components of the herbal product Nausea and vomiting and intolerance to food Resistant hypoxemia and decreased level of consciousness Hemodynamic instability Hypercapnia - Respiratory fatigue

Design outcomes

Primary

MeasureTime frame
The comparison of the symptoms such as fever, dry cough, diarrhea, vomiting, sore throat, sore throat and larynx, abdominal pain and chest pain, nausea, chills and anorexia. Timepoint: The hypotheses are tested at the beginning of the study and on the second, fourth, and sixth days of treatment. Method of measurement: Questionnaire and observation.;Comparison of blood factors CBC, ESR and CRP. Timepoint: The hypotheses are tested at the beginning of the study and on the second, fourth, and sixth days of treatment. Method of measurement: Biochemical factors measured in a clinical laboratory.;Comparison of heart rate, blood pressure and body temperature. Timepoint: The hypotheses are tested at the beginning of the study and on the second, fourth, and sixth days of treatment. Method of measurement: Pressure gauge and thermometer.;Comparison of respiration rate per minute, percentage of blood oxygen saturation and number of days requiring adjuvant oxygen therapy. Timepoint: The hypotheses are tested at the beginning of the study and on the second, fourth, and sixth days of treatment. Method of measurement: Pulse Oximeter.;Evaluation of drug side effects. Timepoint: Days of the first, second and fourth, sixth days after the start of treatment between the intervention and control groups. Method of measurement: View and questionnaire and .;Comparison of the status of withdrawal from the continuation of the study. Timepoint: After starting treatment between the intervention and control groups. Method of measurement: View and questionnaire.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMorteza Kosari

Kashan University of Medical Sciences

research@kaums.ac.ir+98 31 5554 2999

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026