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The efficacy of Etomidate and Propofol in sedation induction of children undergoing gastrointestinal endoscopy

Comparison the efficacy of Etomidate and Propofol in sedation induction in children undergoing upper gastrointestinal endoscopy

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20200515047452N1
Enrollment
90
Registered
2020-08-23
Start date
2020-08-05
Completion date
Unknown
Last updated
2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complications of sedation during endoscopic procedure. Complications of procedures, not elsewhere classified

Interventions

Intervention 1: Intervention group 1: In this group, Propofol 1%, 1 mg / kg will be injected intravenously immediately before endoscopy. Intervention 2: Intervention group 2: In this group, Etomidate

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 15 Years

Inclusion criteria

Inclusion criteria: Children at the age of 1 to 15 years old Candidate for upper gastrointestinal tract endoscopic procedure Class I & II

Exclusion criteria

Exclusion criteria: History of drug allergy to Propofol or Etomidite Kidney disease Liver disease Adrenal disease Severe pneumonia ICU hospitalization History of Postoperative nausea and vomiting G6PD deficiency

Design outcomes

Primary

MeasureTime frame
Blood pressure changes. Timepoint: Immediately before anesthesia and after anesthesia (first minute, 5th minute, 10th minute and 15th minute) will be monitored and recorded. Method of measurement: Blood pressure monitorinng.;Apnea (the cessation of breathing for 10 secounds). Timepoint: Continuously. Method of measurement: Observation of respiratory movements and pulse oximeter changes.;Frequency of Laryngospasm (closure of the vocal cords and lack of air transfer to the lungs and vice versa). Timepoint: Continuously. Method of measurement: Observation.;Duration of Laryngospasm (during time from closure of the vocal cords and lack of air transfer to the lungs and vice versa to bag valve mask ventilation). Timepoint: Continuously. Method of measurement: Cornometer.;Duration of Anesthesia recovery. Timepoint: once at recovery room. Method of measurement: Cornometer.;Nausea and vomiting. Timepoint: Continuously. Method of measurement: Observation.;Agitation. Timepoint: After anesthesia (first minute, 5th minute, 10th minute and 15th minute) will be monitored and recorded. Method of measurement: Sedation Scale for Agitation score,.;Heart rate changes. Timepoint: Immediately before anesthesia and after anesthesia (first minute, 5th minute, 10th minute and 15th minute) will be monitored and recorded. Method of measurement: puls oximetry.;Respiratory rate changes. Timepoint: Immediately before anesthesia and after anesthesia (first minute, 5th minute, 10th minute and 15th minute) will be monitored and recorded. Method of measurement: Chest movement per minute.;Awakening from sedation. Timepoint: Getting to recovey unit until obey the commands and communication with parents. Method of measurement: Observation.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactTahereh Chavoshi

Shahid Beheshti University of Medical Sciences

t.chavoshi@yahoo.com+98 21 2243 9781

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026